PSEN2 Rabbit Polyclonal Antibody (CAB7719)
- SKU:
- CAB7719
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Signal Transduction
Description
Product Name: | PSEN2 Rabbit Polyclonal Antibody |
SKU: | CAB7719 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 267-384 of human PSEN2 (NP_000438.2). |
Sequence: | VLCP KGPL RMLV ETAQ ERNE PIFP ALIY SSAM VWTV GMAK LDPS SQGA LQLP YDPE MEED SYDS FGEP SYPE VFEP PLTG YPGE ELEE EEER GVKL GLGD FIFY SVLV GKAA ATGS GD |
Tested Applications: | WB IF/ICC ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 IF/ICC,1:50 - 1:200 |
Synonyms: | AD4; PS2; AD3L; STM2; CMD1V; PSEN2 |
Positive Sample: | SH-SY5Y,Mouse brain,Rat brain |
Conjugate: | Unconjugated |
Cellular Localization: | Endoplasmic reticulum membrane, Golgi apparatus membrane, Multi-pass membrane protein. |
Calculated MW: | 50kDa |
Observed MW: | 21kDa/35kDa/50kDa |
Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1 or PSEN2) or the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor such that, they either directly regulate gamma-secretase activity, or themselves act are protease enzymes. Two alternatively spliced transcript variants encoding different isoforms of PSEN2 have been identified.
Purification Method: | Affinity purification |
Gene ID: | 5664 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3. |