Presenilin 1 Rabbit Monoclonal Antibody (CAB19103)
- SKU:
- CAB19103
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Death
Description
Product Name: | Presenilin 1 Rabbit Monoclonal Antibody |
SKU: | CAB19103 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 1-100 of human Presenilin 1 (P49768). |
Sequence: | MTEL PAPL SYFQ NAQM SEDN HLSN TVRS QNDN RERQ EHND RRSL GHPE PLSN GRPQ GNSR QVVE QDEE EDEE LTLK YGAK HVIM LFVP VTLC MVVV VATI |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 |
Synonyms: | AD3; FAD; PS1; PS-1; S182; PSNL1; ACNINV3; Presenilin 1 |
Positive Sample: | A-431,Jurkat,U-251MG,Mouse testis,Mouse liver,Mouse brain,Rat brain |
Conjugate: | Unconjugated |
Cellular Localization: | Cell membrane, Cell surface, Endoplasmic reticulum membrane, Golgi apparatus membrane, Multi-pass membrane protein. |
Calculated MW: | 53kDa |
Observed MW: | 30kDa/46kDa |
Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1; PSEN2) or in the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor, such that they either directly regulate gamma-secretase activity or themselves are protease enzymes. Several alternatively spliced transcript variants encoding different isoforms have been identified for this gene, the full-length nature of only some have been determined.
Purification Method: | Affinity purification |
Gene ID: | 5663 |
Clone Number: | ARC0440 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3. |