The Presenilin-1 Polyclonal Antibody (CAB2187) is a valuable tool for researchers studying Presenilin-1, a protein involved in the processing of the amyloid precursor protein (APP) and the generation of amyloid beta peptides. This antibody, produced in rabbits, has high specificity for human samples and has been validated for use in Western blot applications.Presenilin-1 plays a crucial role in the pathogenesis of Alzheimer's disease, as mutations in this protein are associated with early-onset familial Alzheimer's disease.
By targeting Presenilin-1 with this antibody, researchers can investigate its function and role in the development of neurodegenerative diseases.The ability to detect and analyze Presenilin-1 in a variety of cell types makes this antibody well-suited for studies in neuroscience and neurodegenerative disorders. The insights gained from research using this antibody may help in the development of novel therapeutic strategies for Alzheimer's disease and other related conditions.
Product Name:
Presenilin 1 Rabbit Polyclonal Antibody
SKU:
CAB2187
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 290-380 of human Presenilin 1 (NP_000012.1).
Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1; PSEN2) or in the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor, such that they either directly regulate gamma-secretase activity or themselves are protease enzymes. Several alternatively spliced transcript variants encoding different isoforms have been identified for this gene, the full-length nature of only some have been determined.
Purification Method:
Affinity purification
Gene ID:
5663
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of lysates from U-87MG cells, using Presenilin 1 Rabbit pAb (CAB2187) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Enhanced Kit (AbGn00021).Exposure time: 30s.
