Presenilin 1 Rabbit Polyclonal Antibody (CAB2187)
- SKU:
- CAB2187
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Death
Description
Product Name: | Presenilin 1 Rabbit Polyclonal Antibody |
SKU: | CAB2187 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 290-380 of human Presenilin 1 (NP_000012.1). |
Sequence: | STMV WLVN MAEG DPEA QRRV SKNS KYNA ESTE RESQ DTVA ENDD GGFS EEWE AQRD SHLG PHRS TPES RAAV QELS SSIL AGED PEER GVK |
Tested Applications: | WB IHC-P IF/ICC ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 IHC-P,1:50 - 1:200 IF/ICC,1:50 - 1:200 |
Synonyms: | AD3; FAD; PS1; PS-1; S182; PSNL1; ACNINV3; Presenilin 1 |
Positive Sample: | U-87MG |
Conjugate: | Unconjugated |
Cellular Localization: | Cell membrane, Cell surface, Endoplasmic reticulum membrane, Golgi apparatus membrane, Multi-pass membrane protein. |
Calculated MW: | 53kDa |
Observed MW: | 52kDa |
Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1; PSEN2) or in the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor, such that they either directly regulate gamma-secretase activity or themselves are protease enzymes. Several alternatively spliced transcript variants encoding different isoforms have been identified for this gene, the full-length nature of only some have been determined.
Purification Method: | Affinity purification |
Gene ID: | 5663 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3. |