The PRELP Polyclonal Antibody (CAB18573) is a valuable tool for researchers studying the role of PRELP, a protein involved in extracellular matrix organization and cell adhesion. This rabbit polyclonal antibody is highly specific to human samples and has been validated for use in applications such as Western blot and immunohistochemistry. By binding to the PRELP protein, this antibody enables high sensitivity detection and analysis in various cell types, making it an essential component for studies in the fields of tissue engineering, developmental biology, and musculoskeletal research.PRELP is known for its functions in maintaining tissue integrity and regulating cell-cell interactions, making it a key player in processes such as cartilage development and wound healing.
Its role in modulating cell behavior and extracellular matrix composition underscores its importance in understanding various biological processes and disease mechanisms. With the PRELP Polyclonal Antibody, researchers can delve deeper into the functions of PRELP and its potential implications in diseases like osteoarthritis and fibrosis, paving the way for innovative therapeutic approaches targeting this protein.
Product Name:
PRELP Rabbit Polyclonal Antibody
SKU:
CAB18573
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 200-360 of human PRELP (NP_002716.1).
The protein encoded by this gene is a leucine-rich repeat protein present in connective tissue extracellular matrix. This protein functions as a molecule anchoring basement membranes to the underlying connective tissue. This protein has been shown to bind type I collagen to basement membranes and type II collagen to cartilage. It also binds the basement membrane heparan sulfate proteoglycan perlecan. This protein is suggested to be involved in the pathogenesis of Hutchinson-Gilford progeria (HGP), which is reported to lack the binding of collagen in basement membranes and cartilage. Alternatively spliced transcript variants encoding the same protein have been observed.
Purification Method:
Affinity purification
Gene ID:
5549
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using PRELP Rabbit pAb (CAB18573) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.
