The PRDX3 Polyclonal Antibody (CAB13074) is a versatile tool for researchers studying peroxiredoxin 3 (PRDX3), an important antioxidant enzyme located in the mitochondria. PRDX3 plays a crucial role in protecting cells from oxidative stress and regulating cell survival. This antibody, produced in rabbits, is highly specific to human samples and has been validated for use in various applications, including Western blotting and immunohistochemistry. By binding specifically to PRDX3, researchers can confidently detect and analyze the expression of this enzyme in different cell types and tissues.
Given the role of PRDX3 in maintaining cellular health and its potential implications in diseases such as cancer, neurodegenerative disorders, and cardiovascular diseases, studying its expression and function is essential for understanding the underlying mechanisms and exploring therapeutic opportunities. The PRDX3 Polyclonal Antibody is a valuable tool for advancing research in the field of oxidative stress and mitochondrial function.
This gene encodes a mitochondrial protein with antioxidant function. The protein is similar to the C22 subunit of Salmonella typhimurium alkylhydroperoxide reductase, and it can rescue bacterial resistance to alkylhydroperoxide in E. coli that lack the C22 subunit. The human and mouse genes are highly conserved, and they map to the regions syntenic between mouse and human chromosomes. Sequence comparisons with recently cloned mammalian homologs suggest that these genes consist of a family that is responsible for the regulation of cellular proliferation, differentiation and antioxidant functions. This family member can protect cells from oxidative stress, and it can promote cell survival in prostate cancer. Alternative splicing of this gene results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 1, 3, 13 and 22.
Purification Method:
Affinity purification
Gene ID:
10935
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using Peroxiredoxin 3 (PRDX3) Rabbit pAb (CAB13074) at 1:3000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
