The PRDM2 Polyclonal Antibody (CAB8565) is a valuable tool for research involving the PRDM2 protein, a transcriptional regulator that plays a key role in cell differentiation and development. This antibody, raised in rabbits, demonstrates high reactivity with human samples and is specifically validated for use in Western blot applications.PRDM2, also known as RIZ1, is a tumor suppressor gene that is frequently downregulated in various cancers, making it a potential target for cancer therapy. By binding to the PRDM2 protein, this antibody enables researchers to detect and analyze PRDM2 levels in different cell types, providing valuable insights into its function and potential therapeutic applications in cancer research.
The PRDM2 Polyclonal Antibody is an essential tool for studying the role of PRDM2 in tumorigenesis, epigenetic regulation, and cellular differentiation. Its specificity and reliability make it ideal for immunology and cancer research, contributing to a better understanding of the molecular mechanisms underlying cancer development and progression.
Product Name:
PRDM2 Rabbit Polyclonal Antibody
SKU:
CAB8565
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-240 of human PRDM2 (NP_036363.2).
This tumor suppressor gene is a member of a nuclear histone/protein methyltransferase superfamily. It encodes a zinc finger protein that can bind to retinoblastoma protein, estrogen receptor, and the TPA-responsive element (MTE) of the heme-oxygenase-1 gene. Although the functions of this protein have not been fully characterized, it may (1) play a role in transcriptional regulation during neuronal differentiation and pathogenesis of retinoblastoma, (2) act as a transcriptional activator of the heme-oxygenase-1 gene, and (3) be a specific effector of estrogen action. Multiple transcript variants encoding different isoforms have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
7799
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of lysates from rat heart, using PRDM2 Rabbit pAb (CAB8565) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Enhanced Kit (AbGn00021).Exposure time: 90s.
