Anti-PRDM14 Antibody (CAB17203)
- SKU:
- CAB17203
- Product Type:
- Antibody
- Reactivity:
- Human
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Epigenetics and Nuclear Signaling
Description
Anti-PRDM14 Antibody (CAB17203)
The PRDM14 Polyclonal Antibody (CAB17203) is specifically designed for researchers studying PRDM14, a key transcription factor involved in cell fate determination and development. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By binding to the PRDM14 protein, this antibody allows for precise detection and analysis in various cell types, making it an essential tool for studying developmental biology, stem cell research, and cancer biology.
PRDM14 plays a critical role in maintaining pluripotency and self-renewal in embryonic stem cells, as well as in promoting the reprogramming of somatic cells to induced pluripotent stem cells. Its dysregulation has been implicated in various cancers, making it a potential target for therapeutic interventions. By gaining insight into the functions of PRDM14, researchers can further explore its implications in cellular differentiation, tissue regeneration, and tumorigenesis.
| Antibody Name: | Anti-PRDM14 Antibody |
| Antibody SKU: | CAB17203 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant protein of human PRDM14. |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Rat |
| Positive Samples: | MCF7, HepG2, Jurkat, OVCAR3 |
| Immunogen: | Recombinant protein of human PRDM14. |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 63978 |
| Uniprot: | Q9GZV8 |
| Cellular Location: | Nucleus |
| Calculated MW: | 64kDa |
| Observed MW: | 75kDa |
 | Western blot - PRDM14 Rabbit pAb (CAB17203) |
| Synonyms: | PRDM14, PFM11 |
| Background: | This gene encodes a member of the PRDI-BF1 and RIZ homology domain containing (PRDM) family of transcriptional regulators. The encoded protein may possess histone methyltransferase activity and plays a critical role in cell pluripotency by suppressing the expression of differentiation marker genes. Expression of this gene may play a role in breast cancer. |
| UniProt Protein Function: | PRDM14: a probable protein lysine methyltransferase that works in concert with the core human embryonic stem cell (ESC) regulators to control pluripotency associated genes. Binds to silenced genes in human ESCs. Its binding profile is enriched for the repressive tri-methylation of histone H3 lysine 27 (H3K27me3) modification. Interacts directly with the polycomb repressive complex 2 (PRC2). PRC2 is detected at PRDM14-bound loci in human ESCs. A probable transcriptional regulator of the krueppel C2H2-type zinc-finger protein family. Has both positive and negative roles on transcription. Required for the maintenance of emryonic stem cell identity and the reacquisition of pluripotency in somatic cells. May play an essential role in germ cell development at 2 levels: the reacquisition of potential pluripotency, including SOX2 up-regulation, and successful epigenetic reprogramming. Directly up-regulates the expression of pluripotency gene POU5F1 through its proximal enhancer. Binds to the DNA consensus sequence 5'-GGTC[TC]CTAA-3'. |
| UniProt Protein Details: | Protein type:Methyltransferase, protein arginine, predicted; C2H2-type zinc finger protein Chromosomal Location of Human Ortholog: 8q13.3 Cellular Component: nucleoplasm Molecular Function:methyltransferase activity; protein binding; DNA binding; metal ion binding Biological Process: fertilization; regulation of transcription, DNA-dependent; transcription, DNA-dependent; homeostasis of number of cells within a tissue; negative regulation of fibroblast growth factor receptor signaling pathway; somatic stem cell maintenance; inner cell mass cell fate commitment; cell morphogenesis; germ-line stem cell maintenance; cell fate specification; regulation of gene expression, epigenetic; germ cell development |
| NCBI Summary: | This gene encodes a member of the PRDI-BF1 and RIZ homology domain containing (PRDM) family of transcriptional regulators. The encoded protein may possess histone methyltransferase activity and plays a critical role in cell pluripotency by suppressing the expression of differentiation marker genes. Expression of this gene may play a role in breast cancer. [provided by RefSeq, Dec 2011] |
| UniProt Code: | Q9GZV8 |
| NCBI GenInfo Identifier: | 17368925 |
| NCBI Gene ID: | 63978 |
| NCBI Accession: | Q9GZV8.1 |
| UniProt Secondary Accession: | Q9GZV8,Q86UX9, |
| UniProt Related Accession: | Q9GZV8 |
| Molecular Weight: | 571 |
| NCBI Full Name: | PR domain zinc finger protein 14 |
| NCBI Synonym Full Names: | PR domain containing 14 |
| NCBI Official Symbol: | PRDM14Â Â |
| NCBI Official Synonym Symbols: | PFM11Â Â |
| NCBI Protein Information: | PR domain zinc finger protein 14; PR domain-containing 14; PR domain-containing protein 14 |
| UniProt Protein Name: | PR domain zinc finger protein 14 |
| UniProt Synonym Protein Names: | PR domain-containing protein 14 |
| Protein Family: | PR domain zinc finger protein |
| UniProt Gene Name: | PRDM14Â Â |
| UniProt Entry Name: | PRD14_HUMAN |
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