The PRDM12 Polyclonal Antibody (CAB17746) is a valuable tool for researchers studying PRDM12, a transcription factor essential for the development of sensory neurons. This antibody, raised in rabbits, is highly specific to human samples and has been validated for use in Western blot applications. By binding to the PRDM12 protein, this antibody enables accurate detection and analysis in a variety of cell types, making it ideal for studies in neurobiology and developmental biology.PRDM12 is known for its role in the specification and differentiation of sensory neurons, making it a crucial factor in understanding sensory processes and disorders.
Dysfunction of PRDM12 has been linked to conditions such as congenital insensitivity to pain, emphasizing the importance of studying this transcription factor in sensory neuron development. The PRDM12 Polyclonal Antibody provides researchers with a reliable tool for investigating the function and regulation of PRDM12 in both physiological and pathological contexts.
Product Name:
PRDM12 Rabbit Polyclonal Antibody
SKU:
CAB17746
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 100-330 of human PRDM12 (NP_067632.2).
This gene encodes a transcriptional regulator of sensory neuronal specification that plays a critical role in pain perception. The encoded protein contains an N-terminal PRDI-BF1 and RIZ homology (PR) domain, a SET domain, and three C-terminal C2H2 zinc finger DNA-binding domains. Naturally occurring mutations in this gene are associated with congenital insensitivity to pain (CIP), and hereditary sensory and autonomic neuropathies (HSAN's) affecting peripheral sensory and autonomic neurons. Deregulation of this gene is associated with solid cancers and hematological malignancies including chronic myeloid leukaemia.
Purification Method:
Affinity purification
Gene ID:
59335
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of lysates from U-87MG cells, using PRDM12 Rabbit pAb (CAB17746) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
