The PRA1 Antibody (PAC061782) is a highly specific and sensitive tool for researchers studying the PRA1 protein. This polyclonal antibody, generated in rabbits, is optimized for use in Western blot applications and has been validated for its ability to detect PRA1 in human samples.PRA1, also known as PRAF1, is a protein associated with intracellular trafficking and membrane dynamics. It plays a crucial role in vesicle transport and protein sorting, making it an important target for studies on cellular function and organelle organization. The PRA1 Antibody allows for precise detection and analysis of PRA1 in various cell types, providing valuable insights into its role in cellular processes.
Research involving PRA1 is particularly relevant in the fields of cell biology, membrane trafficking, and organelle biogenesis. By understanding the function and regulation of PRA1, researchers can unravel complex cellular mechanisms and potentially uncover new therapeutic targets for diseases related to membrane trafficking dysregulation. The PRA1 Antibody is a valuable tool for investigating the role of PRA1 in cellular processes and advancing our knowledge in the field of cell biology.
Antibody Name:
PRA1 Antibody (PACO61782)
Antibody SKU:
PACO61782
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, WB
Recommended Dilutions:
ELISA:1:2000-1:10000, WB:1:500-1:5000
Species Reactivity:
Candida albicans
Immunogen:
Recombinant Candida albicans pH-regulated antigen PRA1 protein (16-299AA)
Western Blot. Positive WB detected in Recombinant protein. All lanes: PRA1 antibody at 4.7µg/ml. Secondary. Goat polyclonal to rabbit IgG at 1/50000 dilution. Predicted band size: 55 kDa. Observed band size: 55 kDa.
Background:
Cell surface protein involved in the host-parasite interaction during candidal infection. With MP65, represents a major component of the biofilm matrix. Sequesters zinc from host tissue and mediates leukocyte adhesion and migration. As a surface protein, binds the two human complement regulators CFH and CFHR1, as well as plasminogen PLG, mediates complement evasion and extra-cellular matrix interaction and/or degradation. As a released protein, enhances complement control in direct vicinity of the yeast and thus generates an additional protective layer which controls host complement attack, assisting the fungus in escaping host surveillance. Binds to host fluid-phase C3 and blocks cleavage of C3 to C3a and C3b, leading to inhibition of complement activation. Mediates also human complement control and complement evasion through binding to C4BPA, another human complement inhibitor, as well as through binding to host integrin alpha-M/beta-2. Decreases complement-mediated adhesion, as well as uptake of C.albicans by human macrophages.
Cell surface protein involved in the host-parasite interaction during candidal infection. With MP65, represents a major component of the biofilm matrix. Sequesters zinc from host tissue and mediates leukocyte adhesion and migration. As a surface protein, binds the two human complement regulators CFH and CFHR1, as well as plasminogen PLG, mediates complement evasion and extra-cellular matrix interaction and/or degradation. As a released protein, enhances complement control in direct vicinity of the yeast and thus generates an additional protective layer which controls host complement attack, assisting the fungus in escaping host surveillance. Binds to host fluid-phase C3 and blocks cleavage of C3 to C3a and C3b, leading to inhibition of complement activation. Mediates also human complement control and complement evasion through binding to C4BPA, another human complement inhibitor, as well as through binding to host integrin alpha-M/beta-2. Decreases complement-mediated adhesion, as well as uptake of C.albicans by human macrophages.
