The PQBP1 Polyclonal Antibody (CAB4369) is specifically designed for use in research involving PQBP1, a protein that plays a critical role in neurological development and function. This antibody is generated in rabbits and is highly reactive with human samples, making it a valuable tool for studies focused on understanding PQBP1's functions and interactions.PQBP1 is known to be involved in various cellular processes, including RNA splicing and transcriptional regulation, making it a key player in neuronal development and function.
Dysregulation of PQBP1 has been linked to neurodevelopmental disorders such as Renpenning syndrome and intellectual disabilities.This polyclonal antibody is validated for use in multiple applications, including Western blot and immunofluorescence, enabling researchers to detect and analyze PQBP1 expression in different cell types and tissues. By studying PQBP1, researchers can gain insights into its role in neurological disorders and potentially identify new therapeutic targets for these conditions.
Product Name:
PQBP1 Rabbit Polyclonal Antibody
SKU:
CAB4369
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-265 of human PQBP1 (NP_005701.1).
This gene encodes a nuclear polyglutamine-binding protein that is involved with transcription activation. The encoded protein contains a WW domain. Mutations in this gene have been found in patients with Renpenning syndrome 1 and other syndromes with X-linked cognitive disability. Multiple alternatively spliced transcript variants that encode different protein isoforms have been described for this gene.
Purification Method:
Affinity purification
Gene ID:
10084
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using PQBP1 antibody (CAB4369) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.
