PPRC1 Antibody (PACO03686)
- SKU:
- PACO03686
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
PPRC1 Antibody (PACO03686)
The PPRC1 Polyclonal Antibody (PACO03686) is a valuable tool for researchers studying the PPRC1 protein, a key regulator of mitochondrial biogenesis and function. This antibody, generated in rabbits, shows high specificity and sensitivity towards human samples, making it an ideal choice for Western blot applications. By targeting the PPRC1 protein, researchers can gain insights into its role in mitochondrial biology and its potential implications in various diseases such as metabolic disorders and neurodegenerative conditions.PPRC1, also known as Peroxisome Proliferator-Activated Receptor Gamma Coactivator-Related Protein 1, is involved in coordinating mitochondrial gene expression and maintaining mitochondrial homeostasis.
Dysregulation of PPRC1 has been linked to mitochondrial dysfunction, which can contribute to the development of metabolic disorders and neurodegenerative diseases. By utilizing the PPRC1 Polyclonal Antibody, researchers can further investigate the mechanisms underlying these conditions and potentially identify therapeutic targets for intervention.
| Antibody Name: | PPRC1 Antibody |
| Antibody SKU: | PACO03686 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC |
| Recommended Dilutions: | IHC:1:100-1:300 |
| Species Reactivity: | Human, Mouse |
| Immunogen: | synthesized peptide derived from the C-terminal region of human PRC. |
| Form: | Liquid |
| Storage Buffer: | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification Method: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
| Synonyms: | PPRC1; KIAA0595; Peroxisome proliferator-activated receptor gamma coactivator-related protein 1; PGC-1-related coactivator; PRC |
| UniProt Protein Function: | PPRC1: Acts as a coactivator during transcriptional activation of nuclear genes related to mitochondrial biogenesis and cell growth. Involved in the transcription coactivation of CREB and NRF1 target genes. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Transcription, coactivator/corepressor Chromosomal Location of Human Ortholog: 10q24.32 Cellular Component: nucleoplasm; nucleus Molecular Function:ligand-dependent nuclear receptor transcription coactivator activity; transcription factor binding Biological Process: mitochondrion organization and biogenesis; positive regulation of transcription factor activity; positive regulation of transcription from RNA polymerase II promoter |
| NCBI Summary: | The protein encoded by this gene is similar to PPAR-gamma coactivator 1 (PPARGC1/PGC-1), a protein that can activate mitochondrial biogenesis in part through a direct interaction with nuclear respiratory factor 1 (NRF1). This protein has been shown to interact with NRF1. It is thought to be a functional relative of PPAR-gamma coactivator 1 that activates mitochondrial biogenesis through NRF1 in response to proliferative signals. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013] |
| UniProt Code: | Q5VV67 |
| NCBI GenInfo Identifier: | 74756889 |
| NCBI Gene ID: | 23082 |
| NCBI Accession: | Q5VV67.1 |
| UniProt Secondary Accession: | Q5VV67,Q5VV66, Q6P3U5, Q6P3W1, Q76N31, Q9BUJ3, Q9BZE5 Q9Y4E0, |
| UniProt Related Accession: | Q5VV67 |
| Molecular Weight: | 164,965 Da |
| NCBI Full Name: | Peroxisome proliferator-activated receptor gamma coactivator-related protein 1 |
| NCBI Synonym Full Names: | peroxisome proliferator-activated receptor gamma, coactivator-related 1 |
| NCBI Official Symbol: | PPRC1 |
| NCBI Official Synonym Symbols: | PRC |
| NCBI Protein Information: | peroxisome proliferator-activated receptor gamma coactivator-related protein 1 |
| UniProt Protein Name: | Peroxisome proliferator-activated receptor gamma coactivator-related protein 1 |
| UniProt Synonym Protein Names: | PGC-1-related coactivator; PRC |
| Protein Family: | Peroxisome proliferator-activated receptor gamma coactivator-related protein |
| UniProt Gene Name: | PPRC1 |
| UniProt Entry Name: | PPRC1_HUMAN |
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