Calcineurin A Rabbit Polyclonal Antibody (CAB1063)
The PPP3CA Polyclonal Antibody (CAB1063) is designed for research involving PPP3CA, a key regulatory subunit of the calcium-dependent phosphatase, calcineurin. This antibody, also raised in rabbits, is highly specific for human samples and has been validated for use in Western blot and immunohistochemistry applications. It binds specifically to the PPP3CA protein, enabling detection and analysis in various cell types, making it an ideal tool for studies in cell signaling, neuronal development, and immune response regulation.PPP3CA, a critical component of the calcineurin signaling pathway, plays a crucial role in cellular processes such as gene transcription, cell growth, and apoptosis. Dysregulation of PPP3CA has been implicated in various diseases, including cancer, autoimmune disorders, and neurodegenerative diseases.
Research into the function and regulation of PPP3CA is essential for understanding its role in disease pathogenesis and for developing targeted therapies that modulate calcineurin signaling.Overall, the PPP3CA Polyclonal Antibody (CAB1063) is a valuable tool for researchers interested in studying the role of PPP3CA in cellular signaling pathways and its potential as a therapeutic target in various diseases. Its high specificity and reactivity make it a reliable choice for experiments exploring the function and regulation of PPP3CA in various biological contexts.
Product Name:
Calcineurin A Rabbit Polyclonal Antibody
SKU:
CAB1063
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-511 of human Calcineurin A (NP_001124163.1).
Enables several functions, including ATPase binding activity; calmodulin binding activity; and calmodulin-dependent protein phosphatase activity. Involved in several processes, including calcineurin-NFAT signaling cascade; peptidyl-serine dephosphorylation; and response to calcium ion. Located in several cellular components, including cytosol; dendritic spine; and nucleoplasm. Part of calcineurin complex. Colocalizes with cytoplasmic side of plasma membrane. Implicated in developmental and epileptic encephalopathy 91. Biomarker of focal segmental glomerulosclerosis and schizophrenia.
Purification Method:
Affinity purification
Gene ID:
5530
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using Calcineurin A antibody (CAB1063) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.
