The PPP2R5E Polyclonal Antibody (CAB15084) is a valuable tool for researchers studying PPP2R5E, a regulatory subunit of protein phosphatase 2 (PP2A) involved in various cellular processes such as cell cycle regulation, DNA damage repair, and cellular signaling pathways. This antibody, produced in rabbits, demonstrates high specificity and reactivity with human samples, making it a reliable choice for Western blot applications.PP2A is a key enzyme involved in the dephosphorylation of proteins, impacting numerous cellular functions and signaling cascades. PPP2R5E, as a regulatory subunit of PP2A, plays a crucial role in modulating the activity and specificity of the enzyme, influencing diverse cellular processes.
The PPP2R5E Polyclonal Antibody allows for the precise detection and analysis of PPP2R5E protein levels in various cell types, facilitating investigations into its function and potential implications in diseases like cancer, neurodegenerative disorders, and metabolic syndromes.By utilizing the PPP2R5E Polyclonal Antibody, researchers can gain insights into the regulatory mechanisms controlled by PPP2R5E within cells, advancing our understanding of its roles in health and disease. This antibody serves as a valuable tool for studies focused on elucidating the complex functions of PPP2R5E and its implications in cellular physiology and pathology.
The protein encoded by this gene belongs to the phosphatase 2A regulatory subunit B family. Protein phosphatase 2A is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The B regulatory subunit might modulate substrate selectivity and catalytic activity. This gene encodes an epsilon isoform of the regulatory subunit B56 subfamily. Multiple transcript variants encoding several different isoforms have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
5529
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using PP2A-B56δ/PR61δ/PPP2R5E Rabbit pAb (CAB15084) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 1s.
