The PPP2R5B Polyclonal Antibody (CAB14252) is a valuable tool for researchers studying the PPP2R5B protein, which is a regulatory subunit of the protein phosphatase 2A (PP2A) complex. This antibody, generated in rabbits, exhibits high reactivity with human samples and is specifically validated for use in Western blot applications.The PPP2R5B protein is involved in the regulation of various cellular processes, including cell growth, division, and signaling. Dysregulation of PP2A has been implicated in multiple diseases, such as cancer, neurodegenerative disorders, and metabolic diseases.
By targeting the PPP2R5B protein, researchers can gain valuable insights into the mechanisms underlying these diseases and potentially identify novel therapeutic targets.The PPP2R5B Polyclonal Antibody enables precise detection and analysis of the PPP2R5B protein in different cell types, making it an ideal choice for studies in cell biology, signal transduction, and disease pathogenesis. By investigating the function and regulation of PPP2R5B, researchers can further our understanding of cellular processes and potentially identify new avenues for therapeutic intervention.
The product of this gene belongs to the phosphatase 2A regulatory subunit B family. Protein phosphatase 2A is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The B regulatory subunit might modulate substrate selectivity and catalytic activity. This gene encodes a beta isoform of the regulatory subunit B56 subfamily.
Purification Method:
Affinity purification
Gene ID:
5526
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of lysates from U-87MG cells, using PP2A-B56β/PR61β/PPP2R5B Rabbit pAb (CAB14252) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 1s.
