The PPP2R4 Polyclonal Antibody (CAB1912) is a versatile tool for researchers studying PPP2R4, a regulatory subunit of protein phosphatase 2A (PP2A) involved in various cellular processes. This antibody, raised in rabbits, is highly specific for human samples and has been validated for use in Western blot applications. By targeting the PPP2R4 protein, this antibody enables precise detection and analysis in different cell types, making it ideal for investigations in molecular biology and signal transduction pathways.PPP2R4 is known to play a crucial role in regulating cell growth, cell division, and cell death by modulating PP2A activity.
Dysregulation of PP2A has been implicated in various diseases, including cancer, neurodegenerative disorders, and metabolic diseases. Therefore, studying the function of PPP2R4 using this antibody can provide valuable insights into disease mechanisms and identify potential therapeutic targets for drug development.Overall, the PPP2R4 Polyclonal Antibody (CAB1912) is a reliable tool for researchers interested in understanding the role of PPP2R4 in cellular processes and disease pathogenesis. Its specificity and sensitivity make it a valuable asset for studies aimed at unraveling the molecular mechanisms underlying health and disease.
Protein phosphatase 2A is one of the four major Ser/Thr phosphatases and is implicated in the negative control of cell growth and division. Protein phosphatase 2A holoenzymes are heterotrimeric proteins composed of a structural subunit A, a catalytic subunit C, and a regulatory subunit B. The regulatory subunit is encoded by a diverse set of genes that have been grouped into the B/PR55, B'/PR61, and B''/PR72 families. These different regulatory subunits confer distinct enzymatic specificities and intracellular localizations to the holozenzyme. The product of this gene belongs to the B' family. This gene encodes a specific phosphotyrosyl phosphatase activator of the dimeric form of protein phosphatase 2A. Alternative splicing results in multiple transcript variants encoding different isoforms.
Purification Method:
Affinity purification
Gene ID:
5524
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Immunofluorescence analysis of U2OS cells using Ser/thr-PP2A activator (PTPA) antibody (CAB1912). Blue: DAPI for nuclear staining.
