The PPP2R2D Polyclonal Antibody (PAC046614) is a valuable tool for researchers studying PPP2R2D, a regulatory subunit of the protein phosphatase 2A (PP2A) complex. This antibody, produced in rabbits, demonstrates high reactivity with human samples and has been validated for use in Western blot applications. By targeting the PPP2R2D protein, this antibody enables precise detection and analysis in a variety of cell types, making it an essential asset for investigations in cell signaling and cancer research.PPP2R2D, a key player in the PP2A complex, is involved in the regulation of numerous cellular processes, including cell cycle progression, apoptosis, and gene expression. Dysregulation of PP2A function, often linked to altered PPP2R2D expression, has been implicated in a range of diseases, such as cancer, neurodegenerative disorders, and metabolic conditions.
Research into the role of PPP2R2D is crucial for unraveling the intricacies of these diseases and identifying potential therapeutic targets for intervention.In summary, the PPP2R2D Polyclonal Antibody (PAC046614) offers a reliable means of studying PPP2R2D and its involvement in critical cellular pathways. Its specificity and sensitivity make it an indispensable tool for scientists aiming to elucidate the functions of PPP2R2D and its impact on disease progression and treatment strategies.
Immunohistochemistry of paraffin-embedded human prostate cancer using PACO46614 at dilution of 1:100.
Immunofluorescent analysis of Hela cells using PACO46614 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
Immunohistochemistry of paraffin-embedded human glioma using PACO46614 at dilution of 1:100.
Background:
B regulatory subunit of protein phosphatase 2A (PP2A) that plays a key role in cell cycle by controlling mitosis entry and exit. The activity of PP2A complexes containing PPP2R2D (PR55-delta) fluctuate during the cell cycle: the activity is high in interphase and low in mitosis. During mitosis, activity of PP2A is inhibited via interaction with phosphorylated ENSA and ARPP19 inhibitors. Within the PP2A complexes, the B regulatory subunits modulate substrate selectivity and catalytic activity, and also may direct the localization of the catalytic enzyme to a particular subcellular compartment (By similarity).
Synonyms:
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform (PP2A subunit B isoform B55-delta) (PP2A subunit B isoform PR55-delta) (PP2A subunit B isoform R2-delta) (PP2A subunit B isoform delta), PPP2R2D, KIAA1541
UniProt Protein Function:
PPP2R2D: B regulatory subunit of protein phosphatase 2A (PP2A) that plays a key role in cell cycle by controlling mitosis entry and exit. The activity of PP2A complexes containing PPP2R2D (PR55- delta) fluctuate during the cell cycle: the activity is high in interphase and low in mitosis. During mitosis, activity of PP2A is inhibited via interaction with phosphorylated ENSA and ARPP19 inhibitors. Within the PP2A complexes, the B regulatory subunits modulate substrate selectivity and catalytic activity, and also may direct the localization of the catalytic enzyme to a particular subcellular compartment. Belongs to the phosphatase 2A regulatory subunit B family.Protein type: Protein phosphatase, regulatory subunitChromosomal Location of Human Ortholog: 10q26.3Cellular Component: protein phosphatase type 2A complex; cytoplasmMolecular Function: protein phosphatase type 2A regulator activityBiological Process: mitosis; regulation of catalytic activity; cell division; mitotic cell cycle; signal transduction; exit from mitosis
