| UniProt Protein Function: | PPP2R2D: B regulatory subunit of protein phosphatase 2A (PP2A) that plays a key role in cell cycle by controlling mitosis entry and exit. The activity of PP2A complexes containing PPP2R2D (PR55- delta) fluctuate during the cell cycle: the activity is high in interphase and low in mitosis. During mitosis, activity of PP2A is inhibited via interaction with phosphorylated ENSA and ARPP19 inhibitors. Within the PP2A complexes, the B regulatory subunits modulate substrate selectivity and catalytic activity, and also may direct the localization of the catalytic enzyme to a particular subcellular compartment. Belongs to the phosphatase 2A regulatory subunit B family.Protein type: Protein phosphatase, regulatory subunitChromosomal Location of Human Ortholog: 10q26.3Cellular Component: protein phosphatase type 2A complex; cytoplasmMolecular Function: protein phosphatase type 2A regulator activityBiological Process: mitosis; regulation of catalytic activity; cell division; mitotic cell cycle; signal transduction; exit from mitosis |
| UniProt Protein Details: | |
| NCBI Summary: | |
| UniProt Code: | Q66LE6 |
| NCBI GenInfo Identifier: | 51093851 |
| NCBI Gene ID: | 55844 |
| NCBI Accession: | NP_060931.2 |
| UniProt Secondary Accession: | Q66LE6,Q5SQJ2, Q9P1Y7, A8KAK0 |
| UniProt Related Accession: | Q66LE6 |
| Molecular Weight: | 52,042 Da |
| NCBI Full Name: | serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform isoform a |
| NCBI Synonym Full Names: | protein phosphatase 2, regulatory subunit B, delta |
| NCBI Official Symbol: | PPP2R2DÂ Â |
| NCBI Official Synonym Symbols: | MDS026Â Â |
| NCBI Protein Information: | serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform; PP2A subunit B isoform delta; PP2A subunit B isoform R2-delta; PP2A subunit B isoform B55-delta; PP2A subunit B isoform PR55-delta; protein phosphatase 2, regulatory subunit B, delta isoform |
| UniProt Protein Name: | Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform |
| UniProt Synonym Protein Names: | PP2A subunit B isoform B55-delta; PP2A subunit B isoform PR55-delta; PP2A subunit B isoform R2-delta; PP2A subunit B isoform delta |
| Protein Family: | Serine/threonine-protein phosphatase |
| UniProt Gene Name: | PPP2R2DÂ Â |
| UniProt Entry Name: | 2ABD_HUMAN |
