The PPP2R2B/PPP2R2C Polyclonal Antibody (CAB18572) is a valuable tool for researchers studying the PPP2R2B and PPP2R2C proteins, which are regulatory subunits of the protein phosphatase 2A (PP2A) enzyme complex. This antibody, produced in rabbits, has high reactivity with human samples and has been validated for use in Western blot applications.PPP2R2B and PPP2R2C are involved in the regulation of key cellular processes, including cell cycle progression, apoptosis, and signaling pathways. Dysregulation of PP2A activity has been linked to various diseases, making these proteins potential targets for therapeutic interventions. By using the PPP2R2B/PPP2R2C Polyclonal Antibody, researchers can detect and analyze the expression of these proteins in different cell types, providing insight into their roles in biology and disease pathology.
Understanding the functions and interactions of PPP2R2B and PPP2R2C is essential for advancing our knowledge of cellular signaling and identifying new therapeutic targets for conditions such as cancer, neurodegenerative disorders, and cardiovascular diseases. The PPP2R2B/PPP2R2C Polyclonal Antibody is a valuable resource for researchers seeking to elucidate the roles of these critical regulatory proteins in health and disease.
Product Name:
PPP2R2B/PPP2R2C Rabbit Polyclonal Antibody
SKU:
CAB18572
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 108-220 of human PPP2R2B/PPP2R2CPPP2R2B (NP_858060.2).
Sequence:
GDKG GRVV IFQR EQES KNQV HRRG EYNV YSTF QSHE PEFD YLKS LEIE EKIN KIRW LPQQ NAAY FLLS TNDK TVKL WKVS ERDK RPEG YNLK DEEG RLRD PATI TTLR VPVL R
Protein phosphatase 3 is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The constant regulatory subunit A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit.The B regulatory subunit might modulate substrate selectivity and catalytic activity.
Purification Method:
Affinity purification
Gene ID:
5521/5522
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using PPP2R2B/PPP2R2C Rabbit pAb (CAB18572) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 5s.
