PP2A-B55β/PR55β/PPP2R2B Rabbit Polyclonal Antibody (CAB10494)
- SKU:
- CAB10494
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Death
Description
Product Name: | PP2A-B55β/PR55β/PPP2R2B Rabbit Polyclonal Antibody |
SKU: | CAB10494 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 160-260 of human PP2A-B55β/PR55β/PP2A-B55β/PR55β/PPP2R2B (NP_858060.2). |
Sequence: | KIRW LPQQ NAAY FLLS TNDK TVKL WKVS ERDK RPEG YNLK DEEG RLRD PATI TTLR VPVL RPMD LMVE ATPR RVFA NAHT YHIN SISV NSDY ETYM SADD L |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:1000 - 1:2000 |
Synonyms: | PR52B; SCA12; B55BETA; PR55BETA; PP2ABBETA; PP2APR55B; PR2ABBETA; PR55-BETA; PP2AB55BETA; PR2AB55BETA; PP2APR55BETA; PR2APR55BETA; PP2A-B55β/PR55β/PPP2R2B |
Positive Sample: | U-87MG,SH-SY5Y,HepG2,Mouse brain,Mouse lung,Rat brain |
Conjugate: | Unconjugated |
Cellular Localization: | Cytoplasm, Membrane, Mitochondrion, Mitochondrion outer membrane, cytoskeleton. |
Calculated MW: | 52kDa |
Observed MW: | 52kDa |
The product of this gene belongs to the phosphatase 2 regulatory subunit B family. Protein phosphatase 2 is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The B regulatory subunit might modulate substrate selectivity and catalytic activity. This gene encodes a beta isoform of the regulatory subunit B55 subfamily. Defects in this gene cause autosomal dominant spinocerebellar ataxia 12 (SCA12), a disease caused by degeneration of the cerebellum, sometimes involving the brainstem and spinal cord, and in resulting in poor coordination of speech and body movements. Multiple alternatively spliced variants, which encode different isoforms, have been identified for this gene. The 5' UTR of some of these variants includes a CAG trinucleotide repeat sequence (7-28 copies) that can be expanded to 55-78 copies in cases of SCA12.
Purification Method: | Affinity purification |
Gene ID: | 5521 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3. |