The PPP2R2A Polyclonal Antibody (CAB2185) is a valuable tool for researchers studying PPP2R2A, a regulatory subunit of the protein phosphatase 2A (PP2A) enzyme complex. This antibody, generated in rabbits, shows high reactivity with human samples and is validated for use in Western blot applications. By binding to PPP2R2A, the antibody allows for the detection and analysis of this important protein in a variety of cell types, making it ideal for studies in cell signaling, protein regulation, and cancer research.PPP2R2A is known to play a crucial role in controlling cell growth, proliferation, and differentiation by modulating the activity of the PP2A enzyme complex.
Dysregulation of PP2A activity has been implicated in various diseases, including cancer, neurodegenerative disorders, and cardiovascular conditions. Therefore, studying the function of PPP2R2A is essential for understanding the underlying mechanisms of these diseases and developing potential therapeutic interventions targeting PP2A signaling pathways.Overall, the PPP2R2A Polyclonal Antibody (CAB2185) offers researchers a reliable tool to investigate the role of PPP2R2A in cellular processes and disease pathogenesis, ultimately contributing to advancements in the field of molecular biology and personalized medicine.
The product of this gene belongs to the phosphatase 2 regulatory subunit B family. Protein phosphatase 2 is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The B regulatory subunit might modulate substrate selectivity and catalytic activity. This gene encodes an alpha isoform of the regulatory subunit B55 subfamily. Alternatively spliced transcript variants have been described.
Purification Method:
Affinity purification
Gene ID:
5520
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of various lysates using PP2A-B55α/PR55α/PPP2R2A Rabbit pAb (CAB2185) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.
