The PPP2R2A Polyclonal Antibody (CAB13530) is specifically designed for research involving PPP2R2A, a regulatory subunit of the enzyme PP2A that plays a crucial role in cell growth and division. This antibody, produced in rabbits, has high reactivity with human samples and is validated for use in Western blot applications. By binding to the PPP2R2A protein, this antibody enables researchers to detect and analyze PPP2R2A in various cell types, making it an ideal tool for studies in cell biology and cancer research.
PPP2R2A, also known as PR55B, is involved in the regulation of PP2A activity, which in turn affects numerous cellular processes including cell cycle progression, apoptosis, and signal transduction. Dysregulation of PPP2R2A has been implicated in various diseases, making it a valuable target for research into cancer, neurodegenerative disorders, and cardiovascular diseases. Understanding the role of PPP2R2A in cellular signaling pathways is essential for developing targeted therapies that address these conditions.
The product of this gene belongs to the phosphatase 2 regulatory subunit B family. Protein phosphatase 2 is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The B regulatory subunit might modulate substrate selectivity and catalytic activity. This gene encodes an alpha isoform of the regulatory subunit B55 subfamily. Alternatively spliced transcript variants have been described.
Purification Method:
Affinity purification
Gene ID:
5520
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using PP2A-B55α/PR55α/PPP2R2A antibody (CAB13530) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.
