The PPP2R1A/PPP2R2A/PPP2R1B Polyclonal Antibody (CAB18571) is a valuable tool for researchers studying protein phosphatase 2 (PP2A) regulatory subunits. This antibody, raised in rabbits, demonstrates high reactivity with human samples and is ideal for use in Western blot applications. By binding to the PPP2R1A, PPP2R2A, and PPP2R1B proteins, this antibody enables accurate detection and analysis in various cell types, making it essential for studies in cell signaling, cancer research, and developmental biology.PP2A is a crucial serine/threonine phosphatase involved in regulating a wide range of cellular processes, including cell growth, division, and apoptosis.
The regulatory subunits PPP2R1A, PPP2R2A, and PPP2R1B play key roles in controlling the activity and specificity of PP2A, making them important targets for research on disease mechanisms and potential therapeutic strategies. Understanding the functions and interactions of these subunits is essential for unraveling the complex signaling networks that contribute to various pathologies, making the PPP2R1A/PPP2R2A/PPP2R1B Polyclonal Antibody a valuable asset for researchers in the field.
Protein phosphatase 2 is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The constant regulatory subunit A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit.The B regulatory subunit might modulate substrate selectivity and catalytic activity.
Purification Method:
Affinity purification
Gene ID:
5518/5520/5519
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using PPP2R1A/PPP2R2A/PPP2R1B Rabbit pAb (CAB18571) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.
