The PPP2R1A Polyclonal Antibody (CAB5799) is specifically designed for research involving PPP2R1A, a regulatory subunit of the protein phosphatase 2A (PP2A) complex. This antibody, raised in rabbits, is highly reactive with human samples and is validated for use in various applications including Western blot, immunohistochemistry, and immunofluorescence.PPP2R1A plays a crucial role in the regulation of cell growth, proliferation, and differentiation by dephosphorylating target proteins. Dysregulation of PPP2R1A has been implicated in various diseases including cancer, neurodegenerative disorders, and metabolic conditions.
By targeting PPP2R1A, researchers can gain insights into its role in cellular signaling pathways and its potential as a therapeutic target for disease intervention.This polyclonal antibody binds specifically to PPP2R1A, allowing for the detection and analysis of this protein in different cell types and tissues. Its versatility and reliability make it an essential tool for studies in cell biology, oncology, and drug development. Gain a deeper understanding of PPP2R1A and its implications in disease pathology with the PPP2R1A Polyclonal Antibody (CAB5799).
Product Name:
PP2A-Aα/PR65α/PPP2R1A Rabbit Polyclonal Antibody
SKU:
CAB5799
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-270 of human PP2A-Aalpha/PR65α/PP2A-Aα/PR65α/PPP2R1A (NP_055040.2).
This gene encodes a constant regulatory subunit of protein phosphatase 2. Protein phosphatase 2 is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The constant regulatory subunit A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit. This gene encodes an alpha isoform of the constant regulatory subunit A. Alternatively spliced transcript variants have been described.
Purification Method:
Affinity purification
Gene ID:
5518
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using PP2A-Aalpha/PR65α/PP2A-Aα/PR65α/PPP2R1A Polyclonal Antibody (CAB5799) at 1:500 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 1s.
