The PPP2CA Polyclonal Antibody (CAB6702) is a valuable tool for researchers studying the PPP2CA protein, a key regulatory subunit of protein phosphatase 2A (PP2A) involved in cell signaling and gene expression. This antibody, generated in rabbits, has high specificity for human samples and is validated for use in Western blot applications. By targeting the PPP2CA protein, researchers can investigate its role in cellular processes such as cell cycle regulation, apoptosis, and DNA repair.PP2A is a major serine/threonine phosphatase that plays a crucial role in the regulation of various signaling pathways, making it a significant target for research in cancer, neurodegenerative diseases, and other disorders.
The PPP2CA Polyclonal Antibody allows for the detection and analysis of PPP2CA levels in different cell types, providing insights into its function and potential implications for disease development and therapy. Researchers can utilize this antibody to further explore the complex mechanisms underlying PPP2CA-mediated cellular pathways and potential therapeutic interventions.
Product Name:
PP2A Catalytic α Rabbit Polyclonal Antibody
SKU:
CAB6702
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-309 of human PP2A Catalytic α (NP_002706.1).
Chromosome, Cytoplasm, Nucleus, centromere, cytoskeleton, spindle pole.
Calculated MW:
36kDa
Observed MW:
36kDa
This gene encodes the phosphatase 2A catalytic subunit. Protein phosphatase 2A is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. This gene encodes an alpha isoform of the catalytic subunit.
Purification Method:
Affinity purification
Gene ID:
5515
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of various lysates, using PP2A Catalytic α Rabbit pAb (CAB6702) at 1:2000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.
