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PPP1R2 Antibody (PACO11423)

SKU:
PACO11423
Product Type:
Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Applications:
ELISA
Antibody Type:
Polyclonal Antibody
Conjugation:
Unconjugated
€459

Description

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PPP1R2 Antibody (PACO11423)

The PPP1R2 Antibody (PACO11423) is a high-quality research tool specifically designed for studies involving the PPP1R2 protein. This polyclonal antibody is produced in rabbits and has been validated for use in various applications, including Western blotting.PPP1R2, also known as protein phosphatase 1 regulatory inhibitor subunit 2, is a critical regulator of protein phosphatase 1 activity, which plays a vital role in cell cycle progression, DNA replication, and cell growth. The PPP1R2 Antibody binds specifically to PPP1R2 protein, allowing for accurate detection and analysis in a variety of cell types and tissues.

Researchers in the fields of cell biology, molecular biology, and cancer research will find this antibody invaluable for investigating the role of PPP1R2 in cellular processes. By understanding the function of PPP1R2, scientists can gain valuable insights into various diseases, including cancer, neurodegenerative disorders, and metabolic syndromes. This antibody is an essential tool for elucidating the mechanisms underlying these conditions and developing targeted therapeutic strategies.

Antibody Name:PPP1R2 Antibody (PACO11423)
Antibody SKU:PACO11423
Size:50ul
Host Species:Rabbit
Tested Applications:ELISA
Recommended Dilutions:
Species Reactivity:Human, Mouse, Rat
Immunogen:Human PPP1R2
Form:Liquid
Storage Buffer:PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20oC, Avoid freeze / thaw cycles.
Purification Method:Antigen Affinity Purified
Clonality:Polyclonal
Isotype:IgG
Conjugate:Non-conjugated
Synonyms:23kd;
UniProt Protein Function:PPP1R2: a member of the protein phosphatase inhibitor 1 family. A dopamine- and cyclic AMP-regulated neuronal phosphoprotein. Both dopaminergic and glutamatergic (NMDA) receptor stimulation regulate the extent of DARPP32 phosphorylation, but in opposite directions. Dopamine D1 receptor stimulation enhances cAMP formation, resulting in the phosphorylation of DARPP32; phosphorylated DARPP32 is a potent protein phosphatase-1 inhibitor. NMDA receptor stimulation elevates intracellular calcium, which leads to activation of calcineurin and dephosphorylation of phospho-DARPP32, thereby reducing the phosphatase-1 inhibitory activity of DARPP32. Two alternatively-spliced isoforms have been described.
UniProt Protein Details:

Protein type:Motility/polarity/chemotaxis; Protein phosphatase, regulatory subunit; Inhibitor

Chromosomal Location of Human Ortholog: 3q29

Cellular Component: protein phosphatase type 1 complex

Molecular Function:protein binding; type 1 serine/threonine specific protein phosphatase inhibitor activity

Biological Process: generation of precursor metabolites and energy; regulation of phosphoprotein phosphatase activity

NCBI Summary:Protein phosphatase-1 (PP1) is one of the main eukaryotic serine/threonine phosphatases. The protein encoded by this gene binds to the catalytic subunit of PP1, strongly inhibiting its activity. Ten related pseudogenes have been found throughout the human genome. Several splice variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2015]
UniProt Code:P41236
NCBI GenInfo Identifier:729856
NCBI Gene ID:5504
NCBI Accession:P41236.2
UniProt Related Accession:P41236
Molecular Weight:23,015 Da
NCBI Full Name:Protein phosphatase inhibitor 2
NCBI Synonym Full Names:protein phosphatase 1 regulatory inhibitor subunit 2
NCBI Official Symbol:PPP1R2  
NCBI Official Synonym Symbols:IPP2; IPP-2  
NCBI Protein Information:protein phosphatase inhibitor 2
UniProt Protein Name:Protein phosphatase inhibitor 2
Protein Family:Protein phosphatase inhibitor
UniProt Gene Name:PPP1R2  
UniProt Entry Name:IPP2_HUMAN

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