PPP1R2 Antibody (PACO04675)
- SKU:
- PACO04675
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- WB
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
PPP1R2 Antibody (PACO04675)
The PPP1R2 Antibody (PACO4675) is a polyclonal antibody designed for research involving PPP1R2, a regulatory subunit of protein phosphatase 1 (PP1) that plays a crucial role in cell cycle regulation and cellular signaling pathways. Raised in rabbits, this antibody is highly specific and reactive with human samples, making it ideal for use in Western blot applications.PPP1R2 is known to interact with PP1 and regulate its activity, which in turn affects various cellular processes such as cell proliferation, apoptosis, and differentiation.
Dysregulation of PPP1R2 has been implicated in diseases like cancer, where abnormal cell cycle progression and signaling pathways contribute to tumorigenesis.By using the PPP1R2 Antibody, researchers can study the role of PPP1R2 in cellular processes and disease development, providing valuable insights for potential therapeutic targets in cancer treatment and other related conditions. Its high specificity and reactivity make it a reliable tool for immunology and cancer research studies.
| Antibody Name: | PPP1R2 Antibody |
| Antibody SKU: | PACO04675 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB |
| Recommended Dilutions: | WB:1:500-1:2000 |
| Species Reactivity: | Human, Mouse, Rat |
| Immunogen: | synthesized peptide derived from human IPP-2 around the non-phosphorylation site of S44. |
| Form: | Liquid |
| Storage Buffer: | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification Method: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
| Synonyms: | PPP1R2; IPP2; Protein phosphatase inhibitor 2; IPP-2 |
| UniProt Protein Function: | PPP1R2: a member of the protein phosphatase inhibitor 1 family. A dopamine- and cyclic AMP-regulated neuronal phosphoprotein. Both dopaminergic and glutamatergic (NMDA) receptor stimulation regulate the extent of DARPP32 phosphorylation, but in opposite directions. Dopamine D1 receptor stimulation enhances cAMP formation, resulting in the phosphorylation of DARPP32; phosphorylated DARPP32 is a potent protein phosphatase-1 inhibitor. NMDA receptor stimulation elevates intracellular calcium, which leads to activation of calcineurin and dephosphorylation of phospho-DARPP32, thereby reducing the phosphatase-1 inhibitory activity of DARPP32. Two alternatively-spliced isoforms have been described. |
| UniProt Protein Details: | Protein type:Motility/polarity/chemotaxis; Protein phosphatase, regulatory subunit; Inhibitor Chromosomal Location of Human Ortholog: 3q29 Cellular Component: protein phosphatase type 1 complex Molecular Function:protein binding; type 1 serine/threonine specific protein phosphatase inhibitor activity Biological Process: generation of precursor metabolites and energy; regulation of phosphoprotein phosphatase activity |
| NCBI Summary: | Protein phosphatase-1 (PP1) is one of the main eukaryotic serine/threonine phosphatases. The protein encoded by this gene binds to the catalytic subunit of PP1, strongly inhibiting its activity. Ten related pseudogenes have been found throughout the human genome. Several splice variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2015] |
| UniProt Code: | P41236 |
| NCBI GenInfo Identifier: | 729856 |
| NCBI Gene ID: | 5504 |
| NCBI Accession: | P41236.2 |
| UniProt Related Accession: | P41236 |
| Molecular Weight: | 23,015 Da |
| NCBI Full Name: | Protein phosphatase inhibitor 2 |
| NCBI Synonym Full Names: | protein phosphatase 1 regulatory inhibitor subunit 2 |
| NCBI Official Symbol: | PPP1R2Â Â |
| NCBI Official Synonym Symbols: | IPP2; IPP-2Â Â |
| NCBI Protein Information: | protein phosphatase inhibitor 2 |
| UniProt Protein Name: | Protein phosphatase inhibitor 2 |
| Protein Family: | Protein phosphatase inhibitor |
| UniProt Gene Name: | PPP1R2Â Â |
| UniProt Entry Name: | IPP2_HUMAN |
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