PPP1R2 (Ab-44) Antibody (PACO21630)
- SKU:
- PACO21630
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- WB
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
PPP1R2 (Ab-44) Antibody (PACO21630)
The PPP1R2 AB-44 Antibody (PAC021630) is a polyclonal antibody designed for research involving the protein PPP1R2. PPP1R2, also known as Protein phosphatase inhibitor 2 or Inhibitor-2, is a regulatory protein that binds to and inhibits Protein Phosphatase 1 (PP1), an enzyme involved in the regulation of numerous cellular processes. The antibody is raised in rabbits and is highly reactive with human samples.This antibody is validated for use in Western blot applications, enabling the detection and analysis of PPP1R2 protein in various cell types. Its specificity and sensitivity make it ideal for studies in cell signaling, protein phosphorylation, and cellular regulation.
By targeting PPP1R2, researchers can further understand its role in cellular processes and potential implications in diseases such as cancer, neurodegenerative disorders, and metabolic syndromes.Overall, the PPP1R2 AB-44 Antibody is a valuable tool for investigating the function and regulation of PPP1R2, offering insights into its involvement in cellular signaling pathways and potential therapeutic applications in various disease contexts.
| Antibody Name: | PPP1R2 (Ab-44) Antibody (PACO21630) |
| Antibody SKU: | PACO21630 |
| Size: | 100ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB |
| Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:500-1:3000 |
| Species Reactivity: | Human |
| Immunogen: | Synthesized peptide derived from Internal of human PPP1R2. |
| Form: | Liquid |
| Storage Buffer: | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Purification Method: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Western blot analysis of extracts from COLO cells, HepG2 cells and HUVEC cells, using PPP1R2 (Ab-44) antibody. |
| Background: | Inhibitor of protein-phosphatase 1. Helps N.R., FEBS Lett. 340:93-98(1994). |
| Synonyms: | I-2; IPP-2; IPP2; Protein phosphatase inhibitor 2; |
| UniProt Protein Function: | PPP1R2: a member of the protein phosphatase inhibitor 1 family. A dopamine- and cyclic AMP-regulated neuronal phosphoprotein. Both dopaminergic and glutamatergic (NMDA) receptor stimulation regulate the extent of DARPP32 phosphorylation, but in opposite directions. Dopamine D1 receptor stimulation enhances cAMP formation, resulting in the phosphorylation of DARPP32; phosphorylated DARPP32 is a potent protein phosphatase-1 inhibitor. NMDA receptor stimulation elevates intracellular calcium, which leads to activation of calcineurin and dephosphorylation of phospho-DARPP32, thereby reducing the phosphatase-1 inhibitory activity of DARPP32. Two alternatively-spliced isoforms have been described. |
| UniProt Protein Details: | Protein type:Motility/polarity/chemotaxis; Protein phosphatase, regulatory subunit; Inhibitor Chromosomal Location of Human Ortholog: 3q29 Cellular Component: protein phosphatase type 1 complex Molecular Function:protein binding; type 1 serine/threonine specific protein phosphatase inhibitor activity Biological Process: generation of precursor metabolites and energy; regulation of phosphoprotein phosphatase activity |
| NCBI Summary: | Protein phosphatase-1 (PP1) is one of the main eukaryotic serine/threonine phosphatases. The protein encoded by this gene binds to the catalytic subunit of PP1, strongly inhibiting its activity. Ten related pseudogenes have been found throughout the human genome. Several splice variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2015] |
| UniProt Code: | P41236 |
| NCBI GenInfo Identifier: | 729856 |
| NCBI Gene ID: | 5504 |
| NCBI Accession: | P41236.2 |
| UniProt Related Accession: | P41236 |
| Molecular Weight: | 23,015 Da |
| NCBI Full Name: | Protein phosphatase inhibitor 2 |
| NCBI Synonym Full Names: | protein phosphatase 1 regulatory inhibitor subunit 2 |
| NCBI Official Symbol: | PPP1R2Â Â |
| NCBI Official Synonym Symbols: | IPP2; IPP-2Â Â |
| NCBI Protein Information: | protein phosphatase inhibitor 2 |
| UniProt Protein Name: | Protein phosphatase inhibitor 2 |
| Protein Family: | Protein phosphatase inhibitor |
| UniProt Gene Name: | PPP1R2Â Â |
| UniProt Entry Name: | IPP2_HUMAN |
| Secondary Antibody |
| Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
| Recommended Products |
| Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
| Anti-HRP-conjugated Beta Actin Antibody (CABC028) |
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