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PPP1R2 (Ab-44) Antibody (PACO21630)

SKU:
PACO21630
Product Type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Applications:
ELISA
WB
Antibody Type:
Polyclonal Antibody
Conjugation:
Unconjugated
€419
Frequently bought together:

Description

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Antibody Name:PPP1R2 (Ab-44) Antibody (PACO21630)
Antibody SKU:PACO21630
Size:100ul
Host Species:Rabbit
Tested Applications:ELISA, WB
Recommended Dilutions:ELISA:1:2000-1:10000, WB:1:500-1:3000
Species Reactivity:Human
Immunogen:Synthesized peptide derived from Internal of human PPP1R2.
Form:Liquid
Storage Buffer:Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purification Method:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:Polyclonal
Isotype:IgG
Conjugate:Non-conjugated
Product ImageWestern blot analysis of extracts from COLO cells, HepG2 cells and HUVEC cells, using PPP1R2 (Ab-44) antibody.
Background:Inhibitor of protein-phosphatase 1. Helps N.R., FEBS Lett. 340:93-98(1994).
Synonyms:I-2; IPP-2; IPP2; Protein phosphatase inhibitor 2;
UniProt Protein Function:PPP1R2: a member of the protein phosphatase inhibitor 1 family. A dopamine- and cyclic AMP-regulated neuronal phosphoprotein. Both dopaminergic and glutamatergic (NMDA) receptor stimulation regulate the extent of DARPP32 phosphorylation, but in opposite directions. Dopamine D1 receptor stimulation enhances cAMP formation, resulting in the phosphorylation of DARPP32; phosphorylated DARPP32 is a potent protein phosphatase-1 inhibitor. NMDA receptor stimulation elevates intracellular calcium, which leads to activation of calcineurin and dephosphorylation of phospho-DARPP32, thereby reducing the phosphatase-1 inhibitory activity of DARPP32. Two alternatively-spliced isoforms have been described.
UniProt Protein Details:

Protein type:Motility/polarity/chemotaxis; Protein phosphatase, regulatory subunit; Inhibitor

Chromosomal Location of Human Ortholog: 3q29

Cellular Component: protein phosphatase type 1 complex

Molecular Function:protein binding; type 1 serine/threonine specific protein phosphatase inhibitor activity

Biological Process: generation of precursor metabolites and energy; regulation of phosphoprotein phosphatase activity

NCBI Summary:Protein phosphatase-1 (PP1) is one of the main eukaryotic serine/threonine phosphatases. The protein encoded by this gene binds to the catalytic subunit of PP1, strongly inhibiting its activity. Ten related pseudogenes have been found throughout the human genome. Several splice variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2015]
UniProt Code:P41236
NCBI GenInfo Identifier:729856
NCBI Gene ID:5504
NCBI Accession:P41236.2
UniProt Related Accession:P41236
Molecular Weight:23,015 Da
NCBI Full Name:Protein phosphatase inhibitor 2
NCBI Synonym Full Names:protein phosphatase 1 regulatory inhibitor subunit 2
NCBI Official Symbol:PPP1R2  
NCBI Official Synonym Symbols:IPP2; IPP-2  
NCBI Protein Information:protein phosphatase inhibitor 2
UniProt Protein Name:Protein phosphatase inhibitor 2
Protein Family:Protein phosphatase inhibitor
UniProt Gene Name:PPP1R2  
UniProt Entry Name:IPP2_HUMAN
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