PPP1R2 (Ab-120/121) Antibody (PACO23620)
- SKU:
- PACO23620
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- WB
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
PPP1R2 (Ab-120/121) Antibody (PACO23620)
The PPP1R2 Polyclonal Antibody (PAC023620) is a valuable tool for researchers studying PPP1R2, a protein phosphatase involved in cell cycle regulation. The antibody, generated in rabbits, is highly specific to human samples and is validated for use in various applications including Western blotting.PPP1R2 is known to interact with protein phosphatase 1 (PP1) and plays a crucial role in cell division and proliferation.
Dysregulation of PPP1R2 has been associated with various diseases, including cancer and developmental disorders. By using this antibody, researchers can explore the function and expression levels of PPP1R2 in different cell types and tissues, providing valuable insights into its role in cell cycle control and potential implications for disease pathogenesis.
| Antibody Name: | PPP1R2 (Ab-120/121) Antibody (PACO23620) |
| Antibody SKU: | PACO23620 |
| Size: | 100ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB, IHC |
| Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:500-1:3000, IHC:1:50-1:100 |
| Species Reactivity: | Human, Mouse, Rat |
| Immunogen: | Synthesized non-phosphopeptide derived from human PPP1R2 around the phosphorylation site of serine 120 and serine 121 (Q-E-S(p)-S(p)-G-E). |
| Form: | Liquid |
| Storage Buffer: | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Purification Method: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Immunohistochemistry analysis of paraffin-embedded human breast carcinoma tissue using PPP1R2 (Ab-120/121) antibody. |
 | Western blot analysis of extracts from JK cells (Lane 2), using PPP1R2 (Ab-120/121) antiobdy. The lane on the left is treated with synthesized peptide. |
 | Western blot analysis of extracts from Jurkat cells, using PPP1R2 (Ab-120/121) antibody. |
| Background: | Inhibitor of protein-phosphatase 1. |
| Synonyms: | I-2; IPP-2; IPP2; Protein phosphatase inhibitor 2; |
| UniProt Protein Function: | PPP1R2: a member of the protein phosphatase inhibitor 1 family. A dopamine- and cyclic AMP-regulated neuronal phosphoprotein. Both dopaminergic and glutamatergic (NMDA) receptor stimulation regulate the extent of DARPP32 phosphorylation, but in opposite directions. Dopamine D1 receptor stimulation enhances cAMP formation, resulting in the phosphorylation of DARPP32; phosphorylated DARPP32 is a potent protein phosphatase-1 inhibitor. NMDA receptor stimulation elevates intracellular calcium, which leads to activation of calcineurin and dephosphorylation of phospho-DARPP32, thereby reducing the phosphatase-1 inhibitory activity of DARPP32. Two alternatively-spliced isoforms have been described. |
| UniProt Protein Details: | Protein type:Motility/polarity/chemotaxis; Protein phosphatase, regulatory subunit; Inhibitor Chromosomal Location of Human Ortholog: 3q29 Cellular Component: protein phosphatase type 1 complex Molecular Function:protein binding; type 1 serine/threonine specific protein phosphatase inhibitor activity Biological Process: generation of precursor metabolites and energy; regulation of phosphoprotein phosphatase activity |
| NCBI Summary: | Protein phosphatase-1 (PP1) is one of the main eukaryotic serine/threonine phosphatases. The protein encoded by this gene binds to the catalytic subunit of PP1, strongly inhibiting its activity. Ten related pseudogenes have been found throughout the human genome. Several splice variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2015] |
| UniProt Code: | P41236 |
| NCBI GenInfo Identifier: | 729856 |
| NCBI Gene ID: | 5504 |
| NCBI Accession: | P41236.2 |
| UniProt Related Accession: | P41236 |
| Molecular Weight: | 23,015 Da |
| NCBI Full Name: | Protein phosphatase inhibitor 2 |
| NCBI Synonym Full Names: | protein phosphatase 1 regulatory inhibitor subunit 2 |
| NCBI Official Symbol: | PPP1R2Â Â |
| NCBI Official Synonym Symbols: | IPP2; IPP-2Â Â |
| NCBI Protein Information: | protein phosphatase inhibitor 2 |
| UniProt Protein Name: | Protein phosphatase inhibitor 2 |
| Protein Family: | Protein phosphatase inhibitor |
| UniProt Gene Name: | PPP1R2Â Â |
| UniProt Entry Name: | IPP2_HUMAN |
| Secondary Antibody |
| Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
| Recommended Products |
| Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
| Anti-HRP-conjugated Beta Actin Antibody (CABC028) |
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