The PPP1R1B Polyclonal Antibody (CAB2580) is a valuable tool for researchers studying the PPP1R1B protein, also known as DARPP-32. This protein plays a crucial role in the regulation of various cellular processes, including neurotransmission, neuronal signaling, and synaptic plasticity.The antibody, produced in rabbits, is highly specific to PPP1R1B and has been validated for use in Western blot and immunohistochemistry applications. It enables the detection and analysis of PPP1R1B in a variety of cell types and tissue samples, making it ideal for research in neurobiology, neuroscience, and psychiatry.
Understanding the function of PPP1R1B is critical for unraveling its involvement in neurological disorders, such as Parkinson's disease, schizophrenia, and addiction. By targeting PPP1R1B, researchers can potentially develop new therapeutic strategies to treat these disorders and improve patient outcomes. Advance your research with the PPP1R1B Polyclonal Antibody (CAB2580) and unlock new insights into the role of PPP1R1B in health and disease.
Product Name:
DARPP32 Rabbit Polyclonal Antibody
SKU:
CAB2580
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-116 of human DARPP32 (NP_115568.2).
This gene encodes a bifunctional signal transduction molecule. Dopaminergic and glutamatergic receptor stimulation regulates its phosphorylation and function as a kinase or phosphatase inhibitor. As a target for dopamine, this gene may serve as a therapeutic target for neurologic and psychiatric disorders. Multiple transcript variants encoding different isoforms have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
84152
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using DARPP32 antibody (CAB2580) at 1:500 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 60s.
