| UniProt Protein Function: | PPP1R16B: Regulator of protein phosphatase 1 (PP1) that acts as a positive regulator of pulmonary endothelial cell (EC) barrier function. Involved in PKA-mediated moesin dephosphorylation which is important in EC barrier protection against thrombin stimulation. Promotes the interaction of PPP1CA with RPSA/LAMR1 and in turn facilitates the dephosphorylation of RPSA/LAMR1. Involved in the regulation of endothelial cell filopodia extension. May be a downstream target for TGF-beta1 signaling cascade in endothelial cells.Protein type: Motility/polarity/chemotaxis; Protein phosphatase, regulatory subunitChromosomal Location of Human Ortholog: 20q11.23Cellular Component: cell projection; nucleus; perinuclear region of cytoplasm; plasma membraneMolecular Function: protein binding; protein phosphatase type 1 regulator activityBiological Process: negative regulation of protein amino acid dephosphorylation; positive regulation of endothelial cell proliferation; positive regulation of protein amino acid dephosphorylation; regulation of filopodium formation; regulation of phosphoinositide 3-kinase cascade |
| UniProt Protein Details: | |
| NCBI Summary: | The protein encoded by this gene is membrane-associated and contains five ankyrin repeats, a protein phosphatase-1-interacting domain, and a carboxy-terminal CAAX box domain. Synthesis of the encoded protein is inhibited by transforming growth factor beta-1. The protein may bind to the membrane through its CAAX box domain and may act as a signaling molecule through interaction with protein phosphatase-1. Alternative splicing results in multiple transcript variants encoding different isoforms that may undergo similar processing to generate mature protein. [provided by RefSeq, Sep 2015] |
| UniProt Code: | Q96T49 |
| NCBI GenInfo Identifier: | 22256977 |
| NCBI Gene ID: | 26051 |
| NCBI Accession: | Q96T49.1 |
| UniProt Secondary Accession: | Q96T49,O94912, Q5W9G4, Q9NQG4, A2RRR6, E9PFS8 |
| UniProt Related Accession: | Q96T49 |
| Molecular Weight: | 58,900 Da |
| NCBI Full Name: | Protein phosphatase 1 regulatory inhibitor subunit 16B |
| NCBI Synonym Full Names: | protein phosphatase 1 regulatory subunit 16B |
| NCBI Official Symbol: | PPP1R16BÂ Â |
| NCBI Official Synonym Symbols: | TIMAP; ANKRD4Â Â |
| NCBI Protein Information: | protein phosphatase 1 regulatory inhibitor subunit 16B |
| UniProt Protein Name: | Protein phosphatase 1 regulatory inhibitor subunit 16B |
| UniProt Synonym Protein Names: | Ankyrin repeat domain-containing protein 4; CAAX box protein TIMAP; TGF-beta-inhibited membrane-associated protein; hTIMAP |
| Protein Family: | Protein phosphatase 1 regulatory inhibitor |
| UniProt Gene Name: | PPP1R16BÂ Â |
| UniProt Entry Name: | PP16B_HUMAN |
