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PPP1R16B Antibody (PACO22524)

SKU:
PACO22524
Product Type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Applications:
ELISA
WB
Antibody Type:
Polyclonal Antibody
Conjugation:
Unconjugated
€419

Description

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PPP1R16B Antibody (PACO22524)

The PPP1R16B Monoclonal Antibody (PACO22524) is a powerful tool for researchers studying the PPP1R16B protein, which is involved in cell cycle regulation and DNA damage response. This antibody, developed and validated in-house, specifically recognizes PPP1R16B in human samples and is ideal for use in various applications, including Western blot and immunofluorescence.PPP1R16B, also known as protein phosphatase 1 regulatory subunit 16B, plays a crucial role in controlling cell division and DNA repair processes. Dysregulation of PPP1R16B has been implicated in cancer development and progression, making it a promising target for cancer research.

By using this antibody, researchers can study the expression and function of PPP1R16B in different cell types and experimental conditions, providing valuable insights into its role in disease pathology. Overall, the PPP1R16B Monoclonal Antibody (PACO22524) is a reliable tool for investigating the biological functions of PPP1R16B and its potential as a therapeutic target in cancer and other diseases.

Antibody Name:PPP1R16B Antibody (PACO22524)
Antibody SKU:PACO22524
Size:100ul
Host Species:Rabbit
Tested Applications:ELISA, WB
Recommended Dilutions:ELISA:1:2000-1:10000, WB:1:500-1:3000
Species Reactivity:Human
Immunogen:Synthesized peptide derived from internal of human PPP1R16B.
Form:Liquid
Storage Buffer:Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purification Method:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:Polyclonal
Isotype:IgG
Conjugate:Non-conjugated
Product ImageWestern blot analysis of extracts from mouse brain cells, using PPP1R16B antibody.
Background:Regulator of protein phosphatase 1 (PP1) that acts as a positive regulator of pulmonary endothelial cell (EC) barrier function. Involved in PKA-mediated moesin dephosphorylation which is important in EC barrier protection against thrombin stimulation. Promotes the interaction of PPP1CA with RPSA/LAMR1 and in turn facilitates the dephosphorylation of RPSA/LAMR1. Involved in the regulation of endothelial cell filopodia extension. May be a downstream target for TGF-beta1 signaling cascade in endothelial cells.
Synonyms:TGF-beta-inhibited membrane-associated protein; hTIMAP; CAAX box protein TIMAP; Ankyrin repeat domain-containing protein 4;
UniProt Protein Function:PPP1R16B: Regulator of protein phosphatase 1 (PP1) that acts as a positive regulator of pulmonary endothelial cell (EC) barrier function. Involved in PKA-mediated moesin dephosphorylation which is important in EC barrier protection against thrombin stimulation. Promotes the interaction of PPP1CA with RPSA/LAMR1 and in turn facilitates the dephosphorylation of RPSA/LAMR1. Involved in the regulation of endothelial cell filopodia extension. May be a downstream target for TGF-beta1 signaling cascade in endothelial cells.Protein type: Motility/polarity/chemotaxis; Protein phosphatase, regulatory subunitChromosomal Location of Human Ortholog: 20q11.23Cellular Component: cell projection; nucleus; perinuclear region of cytoplasm; plasma membraneMolecular Function: protein binding; protein phosphatase type 1 regulator activityBiological Process: negative regulation of protein amino acid dephosphorylation; positive regulation of endothelial cell proliferation; positive regulation of protein amino acid dephosphorylation; regulation of filopodium formation; regulation of phosphoinositide 3-kinase cascade
UniProt Protein Details:
NCBI Summary:The protein encoded by this gene is membrane-associated and contains five ankyrin repeats, a protein phosphatase-1-interacting domain, and a carboxy-terminal CAAX box domain. Synthesis of the encoded protein is inhibited by transforming growth factor beta-1. The protein may bind to the membrane through its CAAX box domain and may act as a signaling molecule through interaction with protein phosphatase-1. Alternative splicing results in multiple transcript variants encoding different isoforms that may undergo similar processing to generate mature protein. [provided by RefSeq, Sep 2015]
UniProt Code:Q96T49
NCBI GenInfo Identifier:22256977
NCBI Gene ID:26051
NCBI Accession:Q96T49.1
UniProt Secondary Accession:Q96T49,O94912, Q5W9G4, Q9NQG4, A2RRR6, E9PFS8
UniProt Related Accession:Q96T49
Molecular Weight:58,900 Da
NCBI Full Name:Protein phosphatase 1 regulatory inhibitor subunit 16B
NCBI Synonym Full Names:protein phosphatase 1 regulatory subunit 16B
NCBI Official Symbol:PPP1R16B  
NCBI Official Synonym Symbols:TIMAP; ANKRD4  
NCBI Protein Information:protein phosphatase 1 regulatory inhibitor subunit 16B
UniProt Protein Name:Protein phosphatase 1 regulatory inhibitor subunit 16B
UniProt Synonym Protein Names:Ankyrin repeat domain-containing protein 4; CAAX box protein TIMAP; TGF-beta-inhibited membrane-associated protein; hTIMAP
Protein Family:Protein phosphatase 1 regulatory inhibitor
UniProt Gene Name:PPP1R16B  
UniProt Entry Name:PP16B_HUMAN
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