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PPP1R16B Antibody (PACO03811)

SKU:
PACO03811
Product Type:
Antibody
Reactivity:
Human
Mouse
Host Species:
Rabbit
Isotype:
IgG
Applications:
ELISA
WB
Antibody Type:
Polyclonal Antibody
Conjugation:
Unconjugated
€269

Description

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PPP1R16B Antibody (PACO03811)

The PPP1R16B Polyclonal Antibody (PACO03811) is a valuable tool for researchers studying the PPP1R16B protein, a critical regulator of cell cycle progression and cellular proliferation. This antibody, produced in rabbits, is highly specific to human samples and has been validated for use in Western blot applications.PPP1R16B, also known as Myolgin, is involved in the coordination of mitotic events and plays a crucial role in ensuring proper cell division. Dysregulation of PPP1R16B has been implicated in various diseases, including cancer, making it an important target for further research.

By using this antibody, researchers can detect and analyze PPP1R16B expression in different cell types, allowing for a better understanding of its function in both normal and disease states.Overall, the PPP1R16B Polyclonal Antibody is a powerful tool for investigating the role of PPP1R16B in cellular processes and disease development, providing valuable insights for therapeutic strategies targeting this protein.

Antibody Name:PPP1R16B Antibody
Antibody SKU:PACO03811
Size:50ug
Host Species:Rabbit
Tested Applications:ELISA, WB
Recommended Dilutions:WB:1:500-1:2000
Species Reactivity:Human, Mouse
Immunogen:synthesized peptide derived from the Internal region of human TIMAP.
Form:Liquid
Storage Buffer:Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:Polyclonal
Isotype:IgG
Conjugate:Non-conjugated
Synonyms:PPP1R16B; ANKRD4; KIAA0823; Protein phosphatase 1 regulatory inhibitor subunit 16B; Ankyrin repeat domain-containing protein 4; CAAX box protein TIMAP; TGF-beta-inhibited membrane-associated protein; hTIMAP
UniProt Protein Function:PPP1R16B: Regulator of protein phosphatase 1 (PP1) that acts as a positive regulator of pulmonary endothelial cell (EC) barrier function. Involved in PKA-mediated moesin dephosphorylation which is important in EC barrier protection against thrombin stimulation. Promotes the interaction of PPP1CA with RPSA/LAMR1 and in turn facilitates the dephosphorylation of RPSA/LAMR1. Involved in the regulation of endothelial cell filopodia extension. May be a downstream target for TGF-beta1 signaling cascade in endothelial cells.Protein type: Motility/polarity/chemotaxis; Protein phosphatase, regulatory subunitChromosomal Location of Human Ortholog: 20q11.23Cellular Component: cell projection; nucleus; perinuclear region of cytoplasm; plasma membraneMolecular Function: protein binding; protein phosphatase type 1 regulator activityBiological Process: negative regulation of protein amino acid dephosphorylation; positive regulation of endothelial cell proliferation; positive regulation of protein amino acid dephosphorylation; regulation of filopodium formation; regulation of phosphoinositide 3-kinase cascade
UniProt Protein Details:
NCBI Summary:The protein encoded by this gene is membrane-associated and contains five ankyrin repeats, a protein phosphatase-1-interacting domain, and a carboxy-terminal CAAX box domain. Synthesis of the encoded protein is inhibited by transforming growth factor beta-1. The protein may bind to the membrane through its CAAX box domain and may act as a signaling molecule through interaction with protein phosphatase-1. Alternative splicing results in multiple transcript variants encoding different isoforms that may undergo similar processing to generate mature protein. [provided by RefSeq, Sep 2015]
UniProt Code:Q96T49
NCBI GenInfo Identifier:22256977
NCBI Gene ID:26051
NCBI Accession:Q96T49.1
UniProt Secondary Accession:Q96T49,O94912, Q5W9G4, Q9NQG4, A2RRR6, E9PFS8
UniProt Related Accession:Q96T49
Molecular Weight:58,900 Da
NCBI Full Name:Protein phosphatase 1 regulatory inhibitor subunit 16B
NCBI Synonym Full Names:protein phosphatase 1 regulatory subunit 16B
NCBI Official Symbol:PPP1R16B  
NCBI Official Synonym Symbols:TIMAP; ANKRD4  
NCBI Protein Information:protein phosphatase 1 regulatory inhibitor subunit 16B
UniProt Protein Name:Protein phosphatase 1 regulatory inhibitor subunit 16B
UniProt Synonym Protein Names:Ankyrin repeat domain-containing protein 4; CAAX box protein TIMAP; TGF-beta-inhibited membrane-associated protein; hTIMAP
Protein Family:Protein phosphatase 1 regulatory inhibitor
UniProt Gene Name:PPP1R16B  
UniProt Entry Name:PP16B_HUMAN

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