The PPP1R14A Polyclonal Antibody (CAB10160) is specifically designed for researchers studying PPP1R14A, a regulatory protein involved in cell signaling pathways and muscle contraction. This antibody is produced in rabbits and has been validated for use in Western blot applications, allowing for accurate detection and analysis of PPP1R14A protein levels in human samples.PPP1R14A, also known as protein phosphatase 1 regulatory subunit 14A, plays a crucial role in regulating smooth muscle contraction and cell motility. Dysfunction of PPP1R14A has been linked to various diseases, including cancer and cardiovascular disorders. By targeting PPP1R14A, researchers can gain insights into the underlying mechanisms of these diseases and potentially identify novel therapeutic targets.
With its high reactivity and specificity, the PPP1R14A Polyclonal Antibody is a valuable tool for immunology and cancer research studies. By enabling the precise measurement of PPP1R14A expression in different cell types and tissues, this antibody facilitates the investigation of PPP1R14A's role in disease development and progression. Researchers can utilize this antibody to deepen their understanding of PPP1R14A function and potentially uncover new treatment approaches for related conditions.
Product Name:
PPP1R14A Rabbit Polyclonal Antibody
SKU:
CAB10160
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-147 of human PPP1R14A (NP_150281.1).
The protein encoded by this gene belongs to the protein phosphatase 1 (PP1) inhibitor family. This protein is an inhibitor of smooth muscle myosin phosphatase, and has higher inhibitory activity when phosphorylated. Inhibition of myosin phosphatase leads to increased myosin phosphorylation and enhanced smooth muscle contraction. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene.
Purification Method:
Affinity purification
Gene ID:
94274
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using PPP1R14A Rabbit pAb (CAB10160) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 180s.
