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PPP1R14A Monoclonal Antibody [P4H10AT] (CPAB0140)

SKU:
CPAB0140
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Host Species:
Mouse
Isotype:
IgG2a
Clone:
P4H10AT
Applications:
WB
ELISA
€149

Description

system_update_alt Datasheet

PPP1R14A Monoclonal Antibody [P4H10AT] (CPAB0140)

The PPP1R14A Antibody (CPAB0140) is specifically designed for researchers studying the protein PPP1R14A, which plays a crucial role in cellular processes such as cell division and muscle contraction. This polyclonal antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications.PPP1R14A, also known as protein phosphatase 1 regulatory subunit 14A, is involved in the regulation of smooth muscle contraction and plays a role in various signaling pathways. The antibody binds specifically to PPP1R14A, allowing for the detection and analysis of this protein in different cell types.

This makes it an essential tool for investigations in cell biology, muscle physiology, and signaling pathway studies.The importance of PPP1R14A in cellular processes makes it a promising target for research into diseases such as cardiovascular disorders, smooth muscle-related disorders, and cancer. Understanding the mechanisms of PPP1R14A activity is critical for developing potential therapeutic strategies that target this protein for the treatment of various diseases.

Product Name:PPP1R14A Antibody
Product Sku:CPAB0140
Size:5μg
Host Species:Mouse
Immunogen:Anti-human PPP1R14A mAb is derived from hybridization of mouse FO myeloma cells with spleen cells from BALB/c mice immunized with recombinant human PPP1R14A amino acids 1-147 purified from Ecoli.
Clone:P4H10AT.
Reactivity:Human
Applications:Western Blot, ELISA
Purification Method:PPP1R14A antibody was purified from mouse ascitic fluids by protein-G affinity chromatography.
Isotype:IgG2a
Background:PPP1R14A is a phosphorylation-dependent inhibitor of smooth muscle myosin phosphatase. Inhibition of PPP1R14A results to increased myosin phosphorylation and enhances smooth muscle contraction in the absence of increased intracellular Ca(2+) concentration. Myosin phosphatase can reverse MYL (myosin light chain) phosphorylation to induce a state of relaxation. However, during agonist-induced contraction at constant Ca2+ concurrent inhibition of myosin phosphatase leads to increases in MYL phosphorylation and tension. These calcium-independent increases in myosin phosphorylation and tension are termed calcium sensitization. Human pregnancy is characterized by the increases of PKN1 expression and CPI-17 phosphorylation in the myometrium. PPP1R14A is mapped to chromosome 19q13.13-q13.2. PPP1R14A binds directly to protein kinase C and casein kinase I. PPP1R14A siRNA decreased the level of merlin phosphorylation and consequently Ras and ERK activity in human tumor cell lines. PKC/CPI-17 medi
Synonyms:Protein phosphatase 1 regulatory subunit 14A, 17 kDa PKC-potentiated inhibitory protein of PP1, CPI17, CPI-17, PPP1INL, PPP1R14A.
Storage Buffer:For periods up to 1 month store at 4°C, for longer periods of time, store at -20°C. Prevent freeze thaw cycles.

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