The PPP1R11 Polyclonal Antibody (PACO31756) is a valuable tool for research involving PPP1R11, a protein phosphatase inhibitor involved in cell cycle regulation. This antibody, generated in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By targeting the PPP1R11 protein, this antibody enables the detection and analysis of PPP1R11 expression in various cell types, making it a versatile tool for studies in cell biology and cancer research.PPP1R11, also known as protein phosphatase 1 regulatory inhibitor subunit 11, plays a crucial role in controlling the activity of protein phosphatase 1, a key enzyme involved in cell division and growth.
Dysregulation of PPP1R11 has been implicated in various diseases, including cancer, where abnormal cell cycle progression contributes to tumor development and progression. Understanding the function and regulation of PPP1R11 is essential for uncovering its role in disease pathogenesis and identifying potential therapeutic targets.
Antibody Name:
PPP1R11 Antibody (PACO31756)
Antibody SKU:
PACO31756
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:2000-1:10000, IHC:1:20-1:200
Species Reactivity:
Human
Immunogen:
Recombinant Human E3 ubiquitin-protein ligase PPP1R11 protein (1-126AA)
Immunohistochemistry of paraffin-embedded human placenta tissue using PACO31756 at dilution of 1:100.
Background:
Atypical E3 ubiquitin-protein ligase which ubiquitinates TLR2 at 'Lys-754' leading to its degradation by the proteasome. Plays a role in regulating inflammatory cytokine release and gram-positive bacterial clearance by functioning, in part, through the ubiquitination and degradation of TLR2. Inhibitor of protein phosphatase 1.
PPP1R11: Inhibitor of protein phosphatase 1.Protein type: Motility/polarity/chemotaxis; Protein phosphatase, regulatory subunitChromosomal Location of Human Ortholog: 6p22.1Cellular Component: cytoplasm; nucleus; protein phosphatase type 1 complexMolecular Function: protein binding; protein phosphatase 1 binding; type 1 serine/threonine specific protein phosphatase inhibitor activityBiological Process: negative regulation of phosphoprotein phosphatase activity
UniProt Protein Details:
NCBI Summary:
This gene encodes a specific inhibitor of protein phosphatase-1 (PP1) with a differential sensitivity toward the metal-independent and metal-dependent forms of PP1. The gene is located within the major histocompatibility complex class I region on chromosome 6. [provided by RefSeq, Jul 2008]
