The PPP1CB Polyclonal Antibody (PACO51842) is a valuable tool for researchers studying PPP1CB, a key enzyme involved in cellular processes such as cell division and signal transduction. This antibody, generated in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By specifically binding to the PPP1CB protein, this antibody enables the accurate detection and analysis of PPP1CB expression in various cell types.PPP1CB, a catalytic subunit of protein phosphatase 1, plays a crucial role in the regulation of numerous signaling pathways involved in cell growth, differentiation, and apoptosis.
Dysregulation of PPP1CB activity has been implicated in various diseases, including cancer and neurodegenerative disorders. Therefore, studying the function of PPP1CB is essential for understanding its role in disease pathogenesis and developing targeted therapies.By utilizing the PPP1CB Polyclonal Antibody (PACO51842) in research, scientists can gain valuable insights into the biological functions of PPP1CB and its potential as a therapeutic target. This antibody is a valuable tool for investigations in areas such as cancer biology, neuroscience, and cell signaling, where PPP1CB has been identified as a key player.
Antibody Name:
Ppp1cb Antibody (PACO51842)
Antibody SKU:
PACO51842
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, WB
Recommended Dilutions:
ELISA:1:2000-1:10000, WB:1:500-1:5000
Species Reactivity:
Mouse, Rat
Immunogen:
Recombinant Mouse Serine/threonine-protein phosphatase PP1-β catalytic subunit protein (2-327AA)
Western Blot. Positive WB detected in: Rat liver tissue. All lanes: Ppp1cb antibody at 3µg/ml. Secondary. Goat polyclonal to rabbit IgG at 1/50000 dilution. Predicted band size: 38 kDa. Observed band size: 38 kDa..
Background:
Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate hundreds of biological targets. Protein phosphatase (PP1) is essential for cell division, it participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Involved in regulation of ionic conductances and long-term synaptic plasticity. Component of the PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase. In balance with CSNK1D and CSNK1E, determines the circadian period length, through the regulation of the speed and rhythmicity of PER1 and PER2 phosphorylation. May dephosphorylate CSNK1D and CSNK1E.
PPP1CB: is a catalytic subunit of protein phosphatase 1 (PP1), a ubiquitous cytosolic serine-threonine phosphatase. Composed a catalytic subunit (PPP1CA, PPP1CB or PPP1CC) which is folded into its native form by inhibitor 2 and glycogen synthetase kinase 3, and then complexed to one or several targeting (or regulatory) subunits: PPP1R12A and PPP1R12B mediate binding to myosin; PPP1R3A, PPP1R3B, PPP1R3C and PPP1R3D mediate binding to glycogen; and PPP1R15A and PPP1R15B mediate binding to EIF2S1. PP1 is essential for cell division, plays critical roles in many cellular processes including glycogen metabolism, muscle contractility and protein synthesis, and is involved in the regulation of ionic conductances and long-term synaptic plasticity. Inhibits the synthesis of proteins involved in synaptic plasticity. Binds to the transcription factor cyclic AMP-dependent response element binding (CREB) and dephosphorylates it. May regulate chromatin condensation through regulation of histone H3 phosphorylation. Differentially expressed in gastric cancer. May participate in the neurodegenerative progress in Alzheimer's disease. Down-regulated in lung squamous cell carcinoma.Protein type: EC 3.1.3.16; EC 3.1.3.53; Motility/polarity/chemotaxis; Nucleolus; Protein phosphatase, Ser/Thr (non-receptor)Chromosomal Location of Human Ortholog: 5|5 B1Cellular Component: cytoplasm; focal adhesion; glycogen granule; nuclear chromosome, telomeric region; nucleus; protein phosphatase type 1 complexMolecular Function: myosin-light-chain-phosphatase activity; phosphoprotein phosphatase activity; phosphoric monoester hydrolase activity; protein binding; protein kinase binding; protein serine/threonine phosphatase activityBiological Process: circadian regulation of gene expression; entrainment of circadian clock by photoperiod; protein amino acid dephosphorylation; regulation of cell adhesion; regulation of circadian rhythm; regulation of glycogen biosynthetic process; regulation of glycogen catabolic process
