PPP1CA Rabbit Polyclonal Antibody (CAB12468)
- SKU:
- CAB12468
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Metabolism
Description
Product Name: | PPP1CA Rabbit Polyclonal Antibody |
SKU: | CAB12468 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 230-330 of human PPP1CA (NP_002699.1). |
Sequence: | EVVA KFLH KHDL DLIC RAHQ VVED GYEF FAKR QLVT LFSA PNYC GEFD NAGA MMSV DETL MCSF QILK PADK NKGK YGQF SGLN PGGR PITP PRNS AKAK K |
Tested Applications: | WB IF/ICC ELISA |
Recommended Dilution: | WB,1:500 - 1:1000 IF/ICC,1:50 - 1:200 |
Synonyms: | PP1A; PP-1A; PPP1A; PP1alpha; PPP1CA |
Positive Sample: | MCF7,HeLa,NIH/3T3,C6 |
Conjugate: | Unconjugated |
Cellular Localization: | Cytoplasm, Nucleus, nucleolus, nucleoplasm. |
Calculated MW: | 38kDa |
Observed MW: | 38kDa |
The protein encoded by this gene is one of the three catalytic subunits of protein phosphatase 1 (PP1). This broadly expressed gene encodes the alpha subunit of the PP1 complex that associates with over 200 regulatory proteins to form holoenzymes which dephosphorylate their biological targets with high specificity. PP1 is a serine/threonine specific protein phosphatase known to be involved in the regulation of a variety of cellular processes, such as cell division, glycogen metabolism, muscle contractility, protein synthesis, and HIV-1 viral transcription. Increased PP1 activity has been observed in the end stage of heart failure. Studies suggest that PP1 is an important regulator of cardiac function and that PP1 deregulation is implicated in diabetes and multiple types of cancer. Three alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Purification Method: | Affinity purification |
Gene ID: | 5499 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3. |