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PPME1 Monoclonal Antibody [PAT29G3AT] (CPAB0251)

SKU:
CPAB0251
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Host Species:
Mouse
Isotype:
IgG1
Clone:
PAT29G3AT
Applications:
WB
ELISA
€149
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Description

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PPME1 Monoclonal Antibody [PAT29G3AT] (CPAB0251)

The PPME1 Polyclonal Antibody (CPAB0251) is a vital tool for researchers studying the PPME1 protein, which is essential for regulating protein phosphatase activity and cellular processes. This antibody, produced in rabbits, exhibits high reactivity with human samples and is validated for Western blot applications. By specifically binding to the PPME1 protein, researchers can effectively detect and analyze its expression in various cell types, making it ideal for investigations in cell signaling pathways and cancer research.PPME1, also known as protein phosphatase methylesterase 1, plays a crucial role in cellular signaling by controlling the activity of protein phosphatases involved in cell cycle progression and gene expression.

Understanding the function of PPME1 is vital for unraveling its involvement in diseases such as cancer, where dysregulation of protein phosphatase activity contributes to tumorigenesis and tumor progression. The PPME1 antibody provides a valuable tool for researchers seeking to elucidate the role of PPME1 in these cellular processes and develop targeted therapies for various diseases.

Product Name:PPME1 Antibody
Product Sku:CPAB0251
Size:5μg
Host Species:Mouse
Immunogen:Anti-human PPME1 mAb, is derived from hybridization of mouse F myeloma cells with spleen cells from BALB/c mice immunized with recombinant human PPME1 amino acids 1-386 purified from Ecoli.
Clone:PAT29G3AT.
Reactivity:Human
Applications:Western Blot, ELISA
Purification Method:PPME1 antibody was purified from mouse ascitic fluids by protein-A affinity chromatography.
Isotype:IgG1
Background:PPME1 catalyzes the demethylation and inactivation of protein phosphatase (PP2A), a multimeric phosphoserine/ threonine protein phosphatase related to growth inhibition and cell cycle arrest. PPME1 can demethylate PP2A catalytic subunit in vitro and okadaic acid treatment can inhibit this reaction. It is conserved from yeast to human and holds a motif found in lipases having a catalytic triad activated serine as their active site nucleophile.
Synonyms:Protein phosphatase methylesterase 1, PME-1, FLJ22226, EC 3.1.1.
Storage Buffer:For periods up to 1 month store at 4°C, for longer periods of time, store at -20°C. Prevent freeze thaw cycles.

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