The PPM1L Polyclonal Antibody (PACO63111) is a valuable tool for researchers studying the PPM1L protein, a phosphatase enzyme involved in various cellular processes such as DNA damage response, cell cycle regulation, and metabolism. This antibody, produced in rabbits, is highly specific to human samples and has been validated for use in Western blot applications.PPM1L, also known as PP2C-like protein phosphatase, is a key player in the maintenance of cellular homeostasis and has been implicated in diseases like cancer, neurodegenerative disorders, and metabolic conditions.
By targeting PPM1L, researchers can gain insight into its role in these diseases and potentially develop novel therapeutic strategies.With its high reactivity and specificity, the PPM1L Polyclonal Antibody is a reliable tool for detecting and analyzing PPM1L protein levels in a variety of cell types. Its use is particularly beneficial for studies in molecular biology, cancer biology, and cell signaling pathways. Gain a deeper understanding of PPM1L's function and its implications in disease pathology with this powerful research tool.
Antibody Name:
PPM1L Antibody (PACO63111)
Antibody SKU:
PACO63111
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:2000-1:10000, IHC:1:20-1:200
Species Reactivity:
Human
Immunogen:
Recombinant Human Protein phosphatase 1L protein (128-343AA)
IHC image of PACO63111 diluted at 1:100 and staining in paraffin-embedded human heart tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
Background:
Acts as a suppressor of the SAPK signaling pathways by associating with and dephosphorylating MAP3K7/TAK1 and MAP3K5, and by attenuating the association between MAP3K7/TAK1 and MAP2K4 or MAP2K6.
PPM1L: Acts as a suppressor of the SAPK signaling pathways by associating with and dephosphorylating MAP3K7/TAK1 and MAP3K5, and by attenuating the association between MAP3K7/TAK1 and MAP2K4 or MAP2K6. Belongs to the PP2C family. 4 isoforms of the human protein are produced by alternative splicing.Protein type: Protein phosphatase, Ser/Thr (non-receptor); Motility/polarity/chemotaxis; EC 3.1.3.16; Membrane protein, integralChromosomal Location of Human Ortholog: 3q26.1Cellular Component: endoplasmic reticulum membraneMolecular Function: protein serine/threonine phosphatase activityBiological Process: sphingolipid biosynthetic process
UniProt Protein Details:
NCBI Summary:
The protein encoded by this gene is a magnesium or manganese-requiring phosphatase that is involved in several signaling pathways. The encoded protein downregulates apoptosis signal-regulating kinase 1, a protein that initiates a signaling cascade that leads to apoptosis when cells are subjected to cytotoxic stresses. This protein also is an endoplasmic reticulum transmembrane protein that helps regulate ceramide transport from the endoplasmic reticulum to the Golgi apparatus. Finally, this gene may be involved in adiposity since it is upregulated in adipose tissues. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2015]
