The PPM1L Polyclonal Antibody (PAC022527) is a valuable tool for researchers studying PPM1L, a key protein involved in various cellular processes such as cell cycle regulation and DNA damage response. This antibody, generated in rabbits, exhibits high specificity and sensitivity for detecting PPM1L in human samples, making it suitable for Western blot applications.PPM1L, also known as protein phosphatase 1-like, is essential for maintaining genomic stability and controlling cell growth and division. Dysregulation of PPM1L has been linked to cancer development and progression, making it a promising target for cancer research.
By utilizing the PPM1L Polyclonal Antibody, scientists can accurately analyze PPM1L expression levels in different cell types and gain insights into its function in cancer biology.Overall, the PPM1L Polyclonal Antibody is a versatile tool for investigating the role of PPM1L in various physiological and pathological processes, providing valuable information for drug development and therapeutic interventions targeting PPM1L-related pathways.
Antibody Name:
PPM1L Antibody (PACO22527)
Antibody SKU:
PACO22527
Size:
100ul
Host Species:
Rabbit
Tested Applications:
ELISA, WB
Recommended Dilutions:
ELISA:1:2000-1:10000, WB:1:500-1:3000
Species Reactivity:
Human, Mouse
Immunogen:
Synthesized peptide derived from internal of human PPM1L.
Form:
Liquid
Storage Buffer:
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Western blot analysis of extracts from Jurkat cells, using PPM1L antibody.
Background:
Acts as a suppressor of the SAPK signaling pathways by associating with and dephosphorylating MAP3K7/TAK1 and MAP3K5, and by attenuating the association between MAP3K7/TAK1 and MAP2K4 or MAP2K6.
PPM1L: Acts as a suppressor of the SAPK signaling pathways by associating with and dephosphorylating MAP3K7/TAK1 and MAP3K5, and by attenuating the association between MAP3K7/TAK1 and MAP2K4 or MAP2K6. Belongs to the PP2C family. 4 isoforms of the human protein are produced by alternative splicing.Protein type: Protein phosphatase, Ser/Thr (non-receptor); Motility/polarity/chemotaxis; EC 3.1.3.16; Membrane protein, integralChromosomal Location of Human Ortholog: 3q26.1Cellular Component: endoplasmic reticulum membraneMolecular Function: protein serine/threonine phosphatase activityBiological Process: sphingolipid biosynthetic process
UniProt Protein Details:
NCBI Summary:
The protein encoded by this gene is a magnesium or manganese-requiring phosphatase that is involved in several signaling pathways. The encoded protein downregulates apoptosis signal-regulating kinase 1, a protein that initiates a signaling cascade that leads to apoptosis when cells are subjected to cytotoxic stresses. This protein also is an endoplasmic reticulum transmembrane protein that helps regulate ceramide transport from the endoplasmic reticulum to the Golgi apparatus. Finally, this gene may be involved in adiposity since it is upregulated in adipose tissues. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2015]
