The PPM1L Polyclonal Antibody (PAC011412) is a valuable tool for research involving the PPM1L protein, a key player in cellular signaling pathways and gene expression regulation. This antibody, generated in rabbits, exhibits high reactivity with human samples and is optimized for Western blot applications. It specifically binds to the PPM1L protein, allowing for precise detection and analysis in various cell types, making it an essential asset for studies in molecular biology and cancer research.PPM1L, also known as Protein Phosphatase Magnesium-dependent 1L, is involved in numerous biological processes, including cell cycle progression, apoptosis, and DNA damage response.
Dysregulation of PPM1L has been linked to diseases such as cancer, neurodegenerative disorders, and metabolic syndromes, making it a promising target for therapeutic interventions. Investigating the function of PPM1L is crucial for unraveling its role in disease development and identifying potential treatment strategies that target this critical protein.
protein phosphatase 1 (formerly 2C)-like;PPM1L;MGC132545;MGC132547;PP2C-epsilon;PP2CE;PPM1-LIKE ;
UniProt Protein Function:
PPM1L: Acts as a suppressor of the SAPK signaling pathways by associating with and dephosphorylating MAP3K7/TAK1 and MAP3K5, and by attenuating the association between MAP3K7/TAK1 and MAP2K4 or MAP2K6. Belongs to the PP2C family. 4 isoforms of the human protein are produced by alternative splicing.Protein type: Protein phosphatase, Ser/Thr (non-receptor); Motility/polarity/chemotaxis; EC 3.1.3.16; Membrane protein, integralChromosomal Location of Human Ortholog: 3q26.1Cellular Component: endoplasmic reticulum membraneMolecular Function: protein serine/threonine phosphatase activityBiological Process: sphingolipid biosynthetic process
UniProt Protein Details:
NCBI Summary:
The protein encoded by this gene is a magnesium or manganese-requiring phosphatase that is involved in several signaling pathways. The encoded protein downregulates apoptosis signal-regulating kinase 1, a protein that initiates a signaling cascade that leads to apoptosis when cells are subjected to cytotoxic stresses. This protein also is an endoplasmic reticulum transmembrane protein that helps regulate ceramide transport from the endoplasmic reticulum to the Golgi apparatus. Finally, this gene may be involved in adiposity since it is upregulated in adipose tissues. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2015]
