The PPM1L Polyclonal Antibody (PACO02528) is an essential tool for researchers studying the PPM1L protein, a key phosphatase involved in cell signaling pathways and DNA repair mechanisms. This antibody, produced in rabbits, exhibits high specificity and sensitivity towards human samples, making it a reliable choice for Western blot experiments.PPM1L, also known as protein phosphatase Mg2+/Mn2+ dependent 1L, is crucial for maintaining cellular homeostasis by dephosphorylating key signaling molecules and regulating DNA damage repair processes.
Its role in various cellular functions makes it a promising target for research in cancer biology, neurodegenerative diseases, and metabolic disorders. By utilizing the PPM1L Polyclonal Antibody, researchers can investigate the expression and localization of PPM1L in different cell types, providing valuable insights into its functional implications.
Antibody Name:
PPM1L Antibody
Antibody SKU:
PACO02528
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, WB
Recommended Dilutions:
WB:1:500-1:2000
Species Reactivity:
Human, Mouse, Rat
Immunogen:
synthesized peptide derived from the Internal region of human PP2Cepsilon.
Form:
Liquid
Storage Buffer:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Synonyms:
PPM1L; PP2CE; Protein phosphatase 1L; Protein phosphatase 1-like; Protein phosphatase 2C isoform epsilon; PP2C-epsilon
UniProt Protein Function:
PPM1L: Acts as a suppressor of the SAPK signaling pathways by associating with and dephosphorylating MAP3K7/TAK1 and MAP3K5, and by attenuating the association between MAP3K7/TAK1 and MAP2K4 or MAP2K6. Belongs to the PP2C family. 4 isoforms of the human protein are produced by alternative splicing.Protein type: Protein phosphatase, Ser/Thr (non-receptor); Motility/polarity/chemotaxis; EC 3.1.3.16; Membrane protein, integralChromosomal Location of Human Ortholog: 3q26.1Cellular Component: endoplasmic reticulum membraneMolecular Function: protein serine/threonine phosphatase activityBiological Process: sphingolipid biosynthetic process
UniProt Protein Details:
NCBI Summary:
The protein encoded by this gene is a magnesium or manganese-requiring phosphatase that is involved in several signaling pathways. The encoded protein downregulates apoptosis signal-regulating kinase 1, a protein that initiates a signaling cascade that leads to apoptosis when cells are subjected to cytotoxic stresses. This protein also is an endoplasmic reticulum transmembrane protein that helps regulate ceramide transport from the endoplasmic reticulum to the Golgi apparatus. Finally, this gene may be involved in adiposity since it is upregulated in adipose tissues. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2015]
