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PPM1G Monoclonal Antibody [Pk1G6AT] (CPAB0141)

SKU:
CPAB0141
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Host Species:
Mouse
Isotype:
IgG1
Clone:
Pk1G6AT
Applications:
WB
ELISA
IHC
€149

Description

system_update_alt Datasheet

PPM1G Monoclonal Antibody [Pk1G6AT] (CPAB0141)

The PPM1G Polyclonal Antibody (CPAB0141) is a valuable tool for researchers studying the PPM1G protein, which plays a key role in cellular processes such as cell cycle regulation and DNA damage response. This antibody, generated in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications.PPM1G, also known as protein phosphatase Mg2+/Mn2+-dependent 1G, is involved in the dephosphorylation of target proteins, leading to the regulation of various signaling pathways. Its function in DNA repair and cell cycle checkpoints makes it a promising target for investigations related to cancer and other proliferative disorders.

By detecting and analyzing the PPM1G protein in different cell types, researchers can gain valuable insights into its role in these processes.Furthermore, understanding the mechanisms by which PPM1G influences cellular functions can provide important insights into disease pathogenesis and potential therapeutic strategies. The PPM1G Polyclonal Antibody is a reliable tool for studying this protein and advancing our understanding of its functions in health and disease.

Product Name:PPM1G Antibody
Product Sku:CPAB0141
Size:5μg
Host Species:Mouse
Immunogen:Anti-human PPM1G mAb is derived from hybridization of mouse F myeloma cells with spleen cells from BALB/c mice immunized with recombinant human PPM1G amino acids 317-546 purified from Ecoli.
Clone:Pk1G6AT.
Reactivity:Human
Applications:Western Blot, ELISA, Immunohistochemistry
Purification Method:PPM1G antibody was purified from mouse ascitic fluids by protein-G affinity chromatography.
Isotype:IgG1
Background:PPM1G is part of the PP2C family of Ser/Thr protein phosphatases which are known to be negative regulators of cell stress response pathways. PPM1G is accountable for the dephosphorylation of Pre-mRNA splicing factors, an important factor for the formation of functional spliceosome. PPM1G regulates cell cycle progression. PPM1G mediates histone dephosphorylation/exchange in response to DNA damage or checkpoint recovery in higher eukaryotes. The degradation of p21/WAF1 induced by PPM1G is mediated in a proteasome-dependent manner. Protein phosphatase 1G regulates assembly and function of the beta-catenin degradation complex.
Synonyms:Protein Phosphatase 1G, PP2CG, PPP2CG, MGC1675, MGC2870, PP2C GAMMA, EC 3.1.3.16, Protein phosphatase 2C isoform gamma, PP2C-gamma, Protein phosphatase magnesium-dependent 1 gamma, Protein phosphatase 1C, PPM1G, PPM1C.
Storage Buffer:For periods up to 1 month store at 4°C, for longer periods of time, store at -20°C. Prevent freeze thaw cycles.

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