PPM1F Rabbit Polyclonal Antibody (CAB15363)
- SKU:
- CAB15363
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Death
Description
Product Name: | PPM1F Rabbit Polyclonal Antibody |
SKU: | CAB15363 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-190 of human PPM1F (NP_055449.1). |
Sequence: | MSSG APQK SSPM ASGA EETP GFLD TLLQ DFPA LLNP EDPL PWKA PGTV LSQE EVEG ELAE LAMG FLGS RKAP PPLA AALA HEAV SQLL QTDL SEFR KLPR EEEE EEED DDEE EKAP VTLL DAQS LAQS FFNR LWEV AGQW QKQV PLAA RASQ RQWL VSIH AIRN TRRK MEDR HVSL PSFN QLFG LSDP VN |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 |
Synonyms: | CAMKP; FEM-2; POPX2; hFEM-2; CaMKPase; PPM1F |
Positive Sample: | MCF7,HeLa,HepG2,K-562 |
Conjugate: | Unconjugated |
Cellular Localization: | cytosol, nucleus, perinuclear region of cytoplasm |
Calculated MW: | 50kDa |
Observed MW: | 55kDa |
The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase can interact with Rho guanine nucleotide exchange factors (PIX), and thus block the effects of p21-activated kinase 1 (PAK), a protein kinase mediating biological effects downstream of Rho GTPases. Calcium/calmodulin-dependent protein kinase II gamma (CAMK2G/CAMK-II) is found to be one of the substrates of this phosphatase. The overexpression of this phosphatase or CAMK2G has been shown to mediate caspase-dependent apoptosis. An alternatively spliced transcript variant has been identified, but its full-length nature has not been determined.
Purification Method: | Affinity purification |
Gene ID: | 9647 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3. |