PPM1A Rabbit Polyclonal Antibody (CAB6699)
- SKU:
- CAB6699
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
Product Name: | PPM1A Rabbit Polyclonal Antibody |
SKU: | CAB6699 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 161-370 of human PPM1A (NP_005029.1). |
Sequence: | ILEN VEVK GEKP AKLC VIAE CGEL KEGD DGGI FPKD GSGD SHPD FPED ADID LKDV DKIL LITE DLKN IGNT FFKS QNWE MAIK KYAE VLRY VDSS KAVI ETAD RAKL QPIA LSCV LNIG ACKL KMSN WQGA IDSC LEAL ELDP SNTK ALYR RAQG WQGL KEYD QALA DLKK AQGI APED KAIQ AELL KVKQ KIKA QKDK EKAV YAKM FA |
Tested Applications: | WB IF/ICC ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 IF/ICC,1:50 - 1:200 |
Synonyms: | PP2CA; PP2Calpha; PP2C-ALPHA; PPM1A |
Positive Sample: | MCF-7,HeLa,HepG2,SH-SY5Y,Mouse liver,Mouse skeletal muscle,Rat brain |
Conjugate: | Unconjugated |
Cellular Localization: | Cytoplasm, Lipid-anchor, Membrane, Nucleus, cytosol. |
Calculated MW: | 42kDa |
Observed MW: | 42kDa |
The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase dephosphorylates, and negatively regulates the activities of, MAP kinases and MAP kinase kinases. It has been shown to inhibit the activation of p38 and JNK kinase cascades induced by environmental stresses. This phosphatase can also dephosphorylate cyclin-dependent kinases, and thus may be involved in cell cycle control. Overexpression of this phosphatase is reported to activate the expression of the tumor suppressor gene TP53/p53, which leads to G2/M cell cycle arrest and apoptosis. Three alternatively spliced transcript variants encoding distinct isoforms have been described.
Purification Method: | Affinity purification |
Gene ID: | 5494 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3. |