PPM1A Monoclonal Antibody (CAB22076)
- SKU:
- CAB22076
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- WB
Description
Product Name: | PPM1A Monoclonal Antibody |
SKU: | CAB22076 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-382 of human PPM1A (NP_066283.1). |
Sequence: | MGAF LDKP KMEK HNAQ GQGN GLRY GLSS MQGW RVEM EDAH TAVI GLPS GLES WSFF AVYD GHAG SQVA KYCC EHLL DHIT NNQD FKGS AGAP SVEN VKNG IRTG FLEI DEHM RVMS EKKH GADR SGST AVGV LISP QHTY FINC GDSR GLLC RNRK VHFF TQDH KPSN PLEK ERIQ NAGG SVMI QRVN GSLA VSRA LGDF DYKC VHGK GPTE QLVS PEPE VHDI ERSE EDDQ FIIL ACDG IWDV MGNE ELCD FVRS RLEV TDDL EKVC NEVV DTCL YKGS RDNM SVIL ICFP NAPK VSPE AVKK EAEL DKYL ECRV EEII KKQG EGVP DLVH VMRT LASE NIPS LPPG GELA SKRN VIEA VYNR LNPY KNDD TDST STDD MW |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:2000 - 1:20000 |
Synonyms: | PP2CA; PP2Calpha; PP2C-ALPHA; PPM1A |
Positive Sample: | Jurkat,A-431 |
Conjugate: | Unconjugated |
Cellular Localization: | Cytoplasm, Lipid-anchor, Membrane, Nucleus, cytosol. |
Calculated MW: | 42kDa |
Observed MW: | 43kDa |
The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase dephosphorylates, and negatively regulates the activities of, MAP kinases and MAP kinase kinases. It has been shown to inhibit the activation of p38 and JNK kinase cascades induced by environmental stresses. This phosphatase can also dephosphorylate cyclin-dependent kinases, and thus may be involved in cell cycle control. Overexpression of this phosphatase is reported to activate the expression of the tumor suppressor gene TP53/p53, which leads to G2/M cell cycle arrest and apoptosis. Three alternatively spliced transcript variants encoding distinct isoforms have been described.
Purification Method: | Affinity purification |
Gene ID: | 5494 |
Clone Number: | ARC55164 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,0.05% BSA,50% glycerol,pH7.3. |