The PPIL3 Polyclonal Antibody (PAC040554) is a valuable tool for researchers studying the PPIL3 protein, which is involved in protein folding and trafficking within the cell. This antibody, developed in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By binding specifically to the PPIL3 protein, researchers can accurately detect and analyze its expression in various cell types, making it an essential component of studies in molecular biology and cell biology.PPIL3, also known as a peptidyl-prolyl cis-trans isomerase, plays a crucial role in the proper folding of proteins, thereby influencing cellular processes such as protein degradation and signaling pathways.
Its involvement in these fundamental cellular functions makes PPIL3 a key target for research in areas like protein misfolding diseases, cancer biology, and drug development. Understanding the function of PPIL3 is essential for unraveling its role in these biological processes and potentially identifying new therapeutic targets.
Western blot. All lanes: PPIL3 antibody at 10µg/ml. Lane 1: U87 whole cell lysate. Lane 2: HL60 whole cell lysate. Lane 3: K562 whole cell lysate. Lane 4: THP-1 whole cell lysate. Lane 5: A549 whole cell lysate. Secondary. Goat polyclonal to rabbit IgG at 1/10000 dilution. Predicted band size: 19 kDa. Observed band size: 19 kDa.
Immunohistochemistry of paraffin-embedded human small intestine tissue using PACO40554 at dilution of 1:100.
Background:
PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. May be involved in pre-mRNA splicing.
PPIL3: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. May be involved in pre-mRNA splicing. Belongs to the cyclophilin-type PPIase family. PPIL3 subfamily. 2 isoforms of the human protein are produced by alternative splicing.Protein type: EC 5.2.1.8; Spliceosome; Isomerase; CyclophilinChromosomal Location of Human Ortholog: 2q33.1Molecular Function: peptidyl-prolyl cis-trans isomerase activity; protein bindingBiological Process: nuclear mRNA splicing, via spliceosome
UniProt Protein Details:
NCBI Summary:
This gene encodes a member of the cyclophilin family. Cyclophilins catalyze the cis-trans isomerization of peptidylprolyl imide bonds in oligopeptides. They have been proposed to act either as catalysts or as molecular chaperones in protein-folding events. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2008]
