The PPIL3 Polyclonal Antibody (PAC011403) is a reliable tool for researchers studying the PPIL3 protein, a peptidylprolyl isomerase involved in protein folding and assembly. This antibody, produced in rabbits, exhibits high specificity and sensitivity when detecting PPIL3 in human samples and has been validated for use in Western blot applications. By binding to the PPIL3 protein, this antibody facilitates the identification and analysis of PPIL3 expression in various cell types, making it an excellent choice for investigations in the fields of molecular biology and protein research.
PPIL3 is a crucial player in protein folding and quality control mechanisms within the cell, making it an intriguing target for studies related to protein stability and function. Dysregulation of PPIL3 has been implicated in various diseases, including neurodegenerative disorders and cancer, highlighting its importance in cellular homeostasis and disease pathogenesis. By gaining insights into the functions of PPIL3, researchers can pave the way for the development of novel therapeutic approaches targeting protein folding pathways.
PPIL3: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. May be involved in pre-mRNA splicing. Belongs to the cyclophilin-type PPIase family. PPIL3 subfamily. 2 isoforms of the human protein are produced by alternative splicing.Protein type: EC 5.2.1.8; Spliceosome; Isomerase; CyclophilinChromosomal Location of Human Ortholog: 2q33.1Molecular Function: peptidyl-prolyl cis-trans isomerase activity; protein bindingBiological Process: nuclear mRNA splicing, via spliceosome
UniProt Protein Details:
NCBI Summary:
This gene encodes a member of the cyclophilin family. Cyclophilins catalyze the cis-trans isomerization of peptidylprolyl imide bonds in oligopeptides. They have been proposed to act either as catalysts or as molecular chaperones in protein-folding events. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2008]
