UniProt Protein Function: | PPEF-1: a Ser/Thr phosphatase. Contains at least two EF-hand calcium-binding motifs in its C terminus. May play a role in specific sensory neuron function and/or development. Shares high sequence similarity with the Drosophila retinal degeneration C (rdgC) gene. Several alternatively spliced isoforms have been described.Protein type: EC 3.1.3.16; Protein phosphatase, dual-specificity; Motility/polarity/chemotaxis; Protein phosphatase, Ser/Thr (non-receptor)Chromosomal Location of Human Ortholog: Xp22Cellular Component: cytosolMolecular Function: protein binding; protein serine/threonine phosphatase activityBiological Process: protein amino acid dephosphorylation; regulation of rhodopsin mediated signaling |
UniProt Protein Details: | |
NCBI Summary: | This gene encodes a member of the serine/threonine protein phosphatase with EF-hand motif family. The protein contains a protein phosphatase catalytic domain, and at least two EF-hand calcium-binding motifs in its C terminus. Although its substrate(s) is unknown, the encoded protein has been suggested to play a role in specific sensory neuron function and/or development. This gene shares high sequence similarity with the Drosophila retinal degeneration C (rdgC) gene. Several alternatively spliced transcript variants, each encoding a distinct isoform, have been described. [provided by RefSeq, Jul 2008] |
UniProt Code: | O14829 |
NCBI GenInfo Identifier: | 12643541 |
NCBI Gene ID: | 5475 |
NCBI Accession: | O14829.1 |
UniProt Secondary Accession: | O14829,O15253, Q9NU21, Q9UJH0, A6NHP4, A8K348 |
UniProt Related Accession: | O14829 |
Molecular Weight: | 68,806 Da |
NCBI Full Name: | Serine/threonine-protein phosphatase with EF-hands 1 |
NCBI Synonym Full Names: | protein phosphatase with EF-hand domain 1 |
NCBI Official Symbol: | PPEF1Â Â |
NCBI Official Synonym Symbols: | PP7; PPEF; PPP7C; PPP7CAÂ Â |
NCBI Protein Information: | serine/threonine-protein phosphatase with EF-hands 1 |
UniProt Protein Name: | Serine/threonine-protein phosphatase with EF-hands 1 |
UniProt Synonym Protein Names: | Protein phosphatase with EF calcium-binding domain; PPEF; Serine/threonine-protein phosphatase 7; PP7 |
Protein Family: | Serine/threonine-protein phosphatase |
UniProt Gene Name: | PPEF1Â Â |
UniProt Entry Name: | PPE1_HUMAN |