The PPEF1 Polyclonal Antibody (PAC011391) is a valuable tool for researchers studying the PPEF1 protein, which plays a crucial role in cell signaling and regulation of ion channels. This antibody, produced in rabbits, demonstrates high reactivity with human samples and has been validated for use in Western blot applications. By binding to the PPEF1 protein, this antibody allows for the detection and analysis of PPEF1 expression in various cell types, making it an ideal choice for studies in molecular biology and neuroscience research.
PPEF1, also known as protein phosphatase with EF-hand domain 1, is involved in the dephosphorylation of target proteins, thereby regulating their activity and function. Its importance in cell signaling pathways and ion channel regulation makes it a promising target for research into neurological disorders, such as epilepsy and neurodegenerative diseases. Investigating the role of PPEF1 can provide valuable insights into the mechanisms underlying these conditions and potential targets for therapeutic interventions.
protein phosphatase, EF-hand calcium binding domain 1;PPEF1;PP7;PPEF;PPP7C ;
UniProt Protein Function:
PPEF-1: a Ser/Thr phosphatase. Contains at least two EF-hand calcium-binding motifs in its C terminus. May play a role in specific sensory neuron function and/or development. Shares high sequence similarity with the Drosophila retinal degeneration C (rdgC) gene. Several alternatively spliced isoforms have been described.Protein type: EC 3.1.3.16; Protein phosphatase, dual-specificity; Motility/polarity/chemotaxis; Protein phosphatase, Ser/Thr (non-receptor)Chromosomal Location of Human Ortholog: Xp22Cellular Component: cytosolMolecular Function: protein binding; protein serine/threonine phosphatase activityBiological Process: protein amino acid dephosphorylation; regulation of rhodopsin mediated signaling
UniProt Protein Details:
NCBI Summary:
This gene encodes a member of the serine/threonine protein phosphatase with EF-hand motif family. The protein contains a protein phosphatase catalytic domain, and at least two EF-hand calcium-binding motifs in its C terminus. Although its substrate(s) is unknown, the encoded protein has been suggested to play a role in specific sensory neuron function and/or development. This gene shares high sequence similarity with the Drosophila retinal degeneration C (rdgC) gene. Several alternatively spliced transcript variants, each encoding a distinct isoform, have been described. [provided by RefSeq, Jul 2008]
